Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897837667> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2897837667 abstract "The categorization of patients with cognitive symptoms is commonly performed based on clinical criteria. The multiple pathways underlying neurodegeneration can be better captured by unbiased data-driven approaches. This could generate novel patient aggregations which better reflect patients status and trajectories. Here, we employ purely data-driven methods to cluster a cohort of healthy controls (HC), subjective memory complainers (SMC), mild cognitive impairment (MCI), and AD dementia (ADD) patients using a combined panel of established and novel cerebrospinal fluid (CSF) biomarkers. This multicenter cross-sectional study is a convenience sample from three independent European academic memory clinics including: HC (N=25), SMC (n=36), MCI (n=44), and ADD (N=37) participants, all clinically identified. Cerebrospinal fluid (CSF) core biomarkers of AD (Aβ1-42, t-tau, p-tau181) and two novel biomarkers (NFL and YKL-40) were assessed. Age and Mini-Mental State Examination (MMSE) were also included. This 7-dimensional space was fed into t-Distributed Stochastic Neighbor Embedding (tSNE) to identify clusters of arbitrary shape/different densities. Biomarker values were compared across clusters using Kruskall Wallis tests. We found eight distinct patient clusters (sizes: 6-27 patients). The division was driven mainly by YKL-40 (p=1.6*10−97), t-tau (p=8.*10−9), and NFL (p=2.28*10−6). Age (p=3x10−8) and p-tau (p=5x10−4) also played a role, while MMSE was borderline influential (p=0.03). Interestingly, Aβ1-42 did not contribute significantly (p=0.2)." @default.
- W2897837667 created "2018-10-26" @default.
- W2897837667 creator A5010629974 @default.
- W2897837667 creator A5020944505 @default.
- W2897837667 creator A5021920622 @default.
- W2897837667 creator A5024848742 @default.
- W2897837667 creator A5025313057 @default.
- W2897837667 creator A5039123084 @default.
- W2897837667 creator A5052883385 @default.
- W2897837667 creator A5064008420 @default.
- W2897837667 creator A5068377025 @default.
- W2897837667 creator A5069086884 @default.
- W2897837667 creator A5074448145 @default.
- W2897837667 creator A5075596948 @default.
- W2897837667 creator A5075804608 @default.
- W2897837667 creator A5078876988 @default.
- W2897837667 creator A5079766290 @default.
- W2897837667 date "2018-07-01" @default.
- W2897837667 modified "2023-10-02" @default.
- W2897837667 title "P4‐186: INNOVATIVE BIOMARKER‐GUIDED DIAGNOSTIC SYSTEM FROM PRECLINICAL TO ALZHEIMER'S DISEASE DEMENTIA" @default.
- W2897837667 doi "https://doi.org/10.1016/j.jalz.2018.06.2591" @default.
- W2897837667 hasPublicationYear "2018" @default.
- W2897837667 type Work @default.
- W2897837667 sameAs 2897837667 @default.
- W2897837667 citedByCount "0" @default.
- W2897837667 crossrefType "journal-article" @default.
- W2897837667 hasAuthorship W2897837667A5010629974 @default.
- W2897837667 hasAuthorship W2897837667A5020944505 @default.
- W2897837667 hasAuthorship W2897837667A5021920622 @default.
- W2897837667 hasAuthorship W2897837667A5024848742 @default.
- W2897837667 hasAuthorship W2897837667A5025313057 @default.
- W2897837667 hasAuthorship W2897837667A5039123084 @default.
- W2897837667 hasAuthorship W2897837667A5052883385 @default.
- W2897837667 hasAuthorship W2897837667A5064008420 @default.
- W2897837667 hasAuthorship W2897837667A5068377025 @default.
- W2897837667 hasAuthorship W2897837667A5069086884 @default.
- W2897837667 hasAuthorship W2897837667A5074448145 @default.
- W2897837667 hasAuthorship W2897837667A5075596948 @default.
- W2897837667 hasAuthorship W2897837667A5075804608 @default.
- W2897837667 hasAuthorship W2897837667A5078876988 @default.
- W2897837667 hasAuthorship W2897837667A5079766290 @default.
- W2897837667 hasConcept C126322002 @default.
- W2897837667 hasConcept C143998085 @default.
- W2897837667 hasConcept C2776656118 @default.
- W2897837667 hasConcept C2776925932 @default.
- W2897837667 hasConcept C2779134260 @default.
- W2897837667 hasConcept C2779483572 @default.
- W2897837667 hasConcept C2779651940 @default.
- W2897837667 hasConcept C2781197716 @default.
- W2897837667 hasConcept C2984915365 @default.
- W2897837667 hasConcept C55493867 @default.
- W2897837667 hasConcept C71924100 @default.
- W2897837667 hasConcept C72563966 @default.
- W2897837667 hasConcept C86803240 @default.
- W2897837667 hasConceptScore W2897837667C126322002 @default.
- W2897837667 hasConceptScore W2897837667C143998085 @default.
- W2897837667 hasConceptScore W2897837667C2776656118 @default.
- W2897837667 hasConceptScore W2897837667C2776925932 @default.
- W2897837667 hasConceptScore W2897837667C2779134260 @default.
- W2897837667 hasConceptScore W2897837667C2779483572 @default.
- W2897837667 hasConceptScore W2897837667C2779651940 @default.
- W2897837667 hasConceptScore W2897837667C2781197716 @default.
- W2897837667 hasConceptScore W2897837667C2984915365 @default.
- W2897837667 hasConceptScore W2897837667C55493867 @default.
- W2897837667 hasConceptScore W2897837667C71924100 @default.
- W2897837667 hasConceptScore W2897837667C72563966 @default.
- W2897837667 hasConceptScore W2897837667C86803240 @default.
- W2897837667 hasIssue "7S_Part_29" @default.
- W2897837667 hasLocation W28978376671 @default.
- W2897837667 hasOpenAccess W2897837667 @default.
- W2897837667 hasPrimaryLocation W28978376671 @default.
- W2897837667 hasRelatedWork W1963672760 @default.
- W2897837667 hasRelatedWork W1965017881 @default.
- W2897837667 hasRelatedWork W2105060351 @default.
- W2897837667 hasRelatedWork W2140292250 @default.
- W2897837667 hasRelatedWork W2179974513 @default.
- W2897837667 hasRelatedWork W2804922289 @default.
- W2897837667 hasRelatedWork W2989446795 @default.
- W2897837667 hasRelatedWork W3185369253 @default.
- W2897837667 hasRelatedWork W4283804555 @default.
- W2897837667 hasRelatedWork W4366769411 @default.
- W2897837667 hasVolume "14" @default.
- W2897837667 isParatext "false" @default.
- W2897837667 isRetracted "false" @default.
- W2897837667 magId "2897837667" @default.
- W2897837667 workType "article" @default.