Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897838116> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2897838116 endingPage "e314" @default.
- W2897838116 startingPage "e314" @default.
- W2897838116 abstract "Treatment of lesions in close proximity to the optic pathways remains challenging with either conventional resection or with stereotactic radiosurgery (SRS). Hypofractionation has been considered as an alternate treatment. A benefit of hypofractionation for perioptic lesions can be expected because of the low alpha/beta ratio of the optic pathway of 1.11 Gy [submitted to ASTRO 2018]. Between 2011 and 2017 a total of 54 patients with perioptic lesions (27 pituitary adenomas, 16 meningiomas, 7 craniopharyngiomas, 1 cavernoma, 1 AVM, 1 metastasis and 1 sarcoma) were treated with hypofractionation (4 treatments with 5 session with mean margin dose to lesion 5x6.75 Gy, 45 treatments with 4 sessions: 4x5.34 Gy, and 5 treatments with 3 sessions: 3x6.20 Gy) at our Gamma Knife center. Mean age was 46y [11-78y], mean lesion volume was 10.26cc [0.42-40.82cc] Treatments were performed with the stereotactic frame left on during the whole treatment period. All treatments concluded satisfactorily and were well tolerated. Spatial frame displacement was measured <0.3mm using CT images. Exact delineation of the optic pathways was performed on high resolution 3D T1 images and additionally since 2016 by applying FGATIR sequences [submitted to ASTRO 2018] using a 3 Tesla scanner. Dose Volume Histograms were elaborated separately for chiasm, both optic nerves and tracts. After a mean imaging follow up period of 22 months [4-64m], local control was achieved in all but 1 lesion (craniopharyngioma), 12 lesions stayed stable. An overall mean reduction in volume of 2.30% per month was observed (pituitary adenomas: mean reduction 3.13%/m, meningiomas: mean reduction 1.09%/m). Mean maximum optic dose for the 3 fractionation schedules was 5x6.15Gy, 4x5.84Gy, 3x7.42Gy. Mean follow up period for vision evaluation was 19 months [5-53m]. Improved vision was observed in 10 cases, worsened vision in 2 cases: 1 caused by increased tumor volume, 1 case was confirmed for RION (maximum point chiasm dose 4x6.4Gy, optic tracts received up to 4x6.3Gy and 4x6.2Gy, respectively). According to our preliminary results, hypofractionated SRS can be considered as an efficient and relatively safe alternate for the treatment of lesions in close proximity of the optic pathways. Additionally to the benefit of the steep dose gradient in stereotactic radiosurgery, hypofractionation permits an even more aggressive treatment of lesions close to the visual system, profiting from its low alpha/beta ratio." @default.
- W2897838116 created "2018-10-26" @default.
- W2897838116 creator A5001600560 @default.
- W2897838116 creator A5005170986 @default.
- W2897838116 creator A5005352939 @default.
- W2897838116 creator A5033837988 @default.
- W2897838116 creator A5042245601 @default.
- W2897838116 creator A5049137163 @default.
- W2897838116 creator A5068928639 @default.
- W2897838116 creator A5087385146 @default.
- W2897838116 creator A5088927749 @default.
- W2897838116 date "2018-11-01" @default.
- W2897838116 modified "2023-09-27" @default.
- W2897838116 title "Efficacy and Safety of Hypofractionated Stereotactic Radiosurgery for Perioptic Lesions" @default.
- W2897838116 doi "https://doi.org/10.1016/j.ijrobp.2018.07.979" @default.
- W2897838116 hasPublicationYear "2018" @default.
- W2897838116 type Work @default.
- W2897838116 sameAs 2897838116 @default.
- W2897838116 citedByCount "0" @default.
- W2897838116 crossrefType "journal-article" @default.
- W2897838116 hasAuthorship W2897838116A5001600560 @default.
- W2897838116 hasAuthorship W2897838116A5005170986 @default.
- W2897838116 hasAuthorship W2897838116A5005352939 @default.
- W2897838116 hasAuthorship W2897838116A5033837988 @default.
- W2897838116 hasAuthorship W2897838116A5042245601 @default.
- W2897838116 hasAuthorship W2897838116A5049137163 @default.
- W2897838116 hasAuthorship W2897838116A5068928639 @default.
- W2897838116 hasAuthorship W2897838116A5087385146 @default.
- W2897838116 hasAuthorship W2897838116A5088927749 @default.
- W2897838116 hasConcept C118487528 @default.
- W2897838116 hasConcept C126838900 @default.
- W2897838116 hasConcept C141071460 @default.
- W2897838116 hasConcept C2777047896 @default.
- W2897838116 hasConcept C2779797997 @default.
- W2897838116 hasConcept C2780387249 @default.
- W2897838116 hasConcept C2780837183 @default.
- W2897838116 hasConcept C2781156865 @default.
- W2897838116 hasConcept C2989005 @default.
- W2897838116 hasConcept C509974204 @default.
- W2897838116 hasConcept C71924100 @default.
- W2897838116 hasConceptScore W2897838116C118487528 @default.
- W2897838116 hasConceptScore W2897838116C126838900 @default.
- W2897838116 hasConceptScore W2897838116C141071460 @default.
- W2897838116 hasConceptScore W2897838116C2777047896 @default.
- W2897838116 hasConceptScore W2897838116C2779797997 @default.
- W2897838116 hasConceptScore W2897838116C2780387249 @default.
- W2897838116 hasConceptScore W2897838116C2780837183 @default.
- W2897838116 hasConceptScore W2897838116C2781156865 @default.
- W2897838116 hasConceptScore W2897838116C2989005 @default.
- W2897838116 hasConceptScore W2897838116C509974204 @default.
- W2897838116 hasConceptScore W2897838116C71924100 @default.
- W2897838116 hasIssue "3" @default.
- W2897838116 hasLocation W28978381161 @default.
- W2897838116 hasOpenAccess W2897838116 @default.
- W2897838116 hasPrimaryLocation W28978381161 @default.
- W2897838116 hasRelatedWork W1971946703 @default.
- W2897838116 hasRelatedWork W1994448744 @default.
- W2897838116 hasRelatedWork W2027014430 @default.
- W2897838116 hasRelatedWork W2040234847 @default.
- W2897838116 hasRelatedWork W2086721428 @default.
- W2897838116 hasRelatedWork W2089713314 @default.
- W2897838116 hasRelatedWork W2167960661 @default.
- W2897838116 hasRelatedWork W2169156098 @default.
- W2897838116 hasRelatedWork W2395677573 @default.
- W2897838116 hasRelatedWork W2492930466 @default.
- W2897838116 hasVolume "102" @default.
- W2897838116 isParatext "false" @default.
- W2897838116 isRetracted "false" @default.
- W2897838116 magId "2897838116" @default.
- W2897838116 workType "article" @default.