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- W2897841177 abstract "Atherosclerosis is currently understood to be mainly the consequence of a complicated inflammatory process at the different stages of plaque development. Among the several inflammatory molecules involved, up-regulation of the functional cyclooxygenase 2/membrane-bound prostaglandin E synthase 1 (COX-2/mPGES-1) axis plays a key role in plaque development. Excessive production of oxidized lipids, following low-density lipoprotein (LDL) oxidation, is a characteristic feature of atherosclerosis. Among the oxidized lipids of LDLs, the oxysterol 27-hydroxycholesterol (27-OH) and the aldehyde 4-hydroxynonenal (HNE) substantially accumulate in the atherosclerotic plaque, contributing to its progression and instability through a variety of processes. This study shows that 27-OH and HNE promote up-regulation of both the inducible enzymes COX-2 and mPGES-1, leading to increased production of prostaglandin (PG) E2 and inducible nitric oxide synthase, and the subsequent release of nitric oxide in human promonocytic U937 cells. The study also examined the potential involvement of the functionally coupled COX-2/mPGES-1 in enhancing the production of certain pro-inflammatory cytokines and of matrix metalloproteinase 9 by U937 cells. This enhancement is presumably due to the induction of PGE2 synthesis, as a result of the up-regulation of the COX-2/mPGES-1, stimulated by the two oxidized lipids, 27-OH and HNE. Induction of PGE2 synthesis might thus be a mechanism of plaque instability and eventual rupture, contributing to matrix metalloproteinase production by activated macrophages." @default.
- W2897841177 created "2018-10-26" @default.
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- W2897841177 date "2018-12-01" @default.
- W2897841177 modified "2023-09-29" @default.
- W2897841177 title "Up-regulation of COX-2 and mPGES-1 by 27-hydroxycholesterol and 4-hydroxynonenal: A crucial role in atherosclerotic plaque instability" @default.
- W2897841177 cites W1495576061 @default.
- W2897841177 cites W1963758475 @default.
- W2897841177 cites W1964797510 @default.
- W2897841177 cites W1968752758 @default.
- W2897841177 cites W1972044040 @default.
- W2897841177 cites W1972505498 @default.
- W2897841177 cites W1976915409 @default.
- W2897841177 cites W1978820535 @default.
- W2897841177 cites W1980372866 @default.
- W2897841177 cites W1980374297 @default.
- W2897841177 cites W1981448470 @default.
- W2897841177 cites W1981493281 @default.
- W2897841177 cites W1982584793 @default.
- W2897841177 cites W1983735472 @default.
- W2897841177 cites W1986022717 @default.
- W2897841177 cites W1987021426 @default.
- W2897841177 cites W1987031993 @default.
- W2897841177 cites W1988370081 @default.
- W2897841177 cites W1990896627 @default.
- W2897841177 cites W1991453413 @default.
- W2897841177 cites W1995313036 @default.
- W2897841177 cites W1995766630 @default.
- W2897841177 cites W1995860668 @default.
- W2897841177 cites W1996692411 @default.
- W2897841177 cites W1998305917 @default.
- W2897841177 cites W1998385984 @default.
- W2897841177 cites W2006306072 @default.
- W2897841177 cites W2006874666 @default.
- W2897841177 cites W2012275514 @default.
- W2897841177 cites W2015008845 @default.
- W2897841177 cites W2019632917 @default.
- W2897841177 cites W2021574337 @default.
- W2897841177 cites W2026847539 @default.
- W2897841177 cites W2042288985 @default.
- W2897841177 cites W2046365552 @default.
- W2897841177 cites W2055285585 @default.
- W2897841177 cites W2057522312 @default.
- W2897841177 cites W2058205407 @default.
- W2897841177 cites W2060163787 @default.
- W2897841177 cites W2061857216 @default.
- W2897841177 cites W2064165080 @default.
- W2897841177 cites W2066963386 @default.
- W2897841177 cites W2068982039 @default.
- W2897841177 cites W2078231557 @default.
- W2897841177 cites W2080788169 @default.
- W2897841177 cites W2083763989 @default.
- W2897841177 cites W2084996949 @default.
- W2897841177 cites W2086317930 @default.
- W2897841177 cites W2089747387 @default.
- W2897841177 cites W2094941678 @default.
- W2897841177 cites W2096960616 @default.
- W2897841177 cites W2097705351 @default.
- W2897841177 cites W2106319388 @default.
- W2897841177 cites W2107277218 @default.
- W2897841177 cites W2113892902 @default.
- W2897841177 cites W2120439472 @default.
- W2897841177 cites W2131116297 @default.
- W2897841177 cites W2139510950 @default.
- W2897841177 cites W2147340189 @default.
- W2897841177 cites W2148744880 @default.
- W2897841177 cites W2163625494 @default.
- W2897841177 cites W2164475521 @default.
- W2897841177 cites W2167029659 @default.
- W2897841177 cites W2305846129 @default.
- W2897841177 cites W2324841714 @default.
- W2897841177 cites W2514296200 @default.
- W2897841177 cites W2518376660 @default.
- W2897841177 cites W2521339456 @default.
- W2897841177 cites W2562551269 @default.
- W2897841177 cites W2567820440 @default.
- W2897841177 cites W2570267130 @default.
- W2897841177 cites W2589289977 @default.
- W2897841177 cites W2619052091 @default.
- W2897841177 cites W2735540449 @default.
- W2897841177 cites W2743509115 @default.
- W2897841177 cites W2750355649 @default.
- W2897841177 cites W2753823906 @default.
- W2897841177 cites W2765125002 @default.
- W2897841177 cites W2770016955 @default.
- W2897841177 cites W2793853755 @default.
- W2897841177 cites W2805987990 @default.
- W2897841177 cites W605670283 @default.
- W2897841177 doi "https://doi.org/10.1016/j.freeradbiomed.2018.09.046" @default.
- W2897841177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312760" @default.
- W2897841177 hasPublicationYear "2018" @default.