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- W2897843430 abstract "Summary Introduction: The antimicrobial, antibacterial, antioxidant, antihyperlipidaemic, antidiabetic, anti-inflammatory and analgesic effects of Satureja khuzestanica ( Lamiaceae ) have been investigated in numerous studies. Objective: The antifungal effects of S. khuzestanica essential oil (SKJO) in immunosuppressed rats suffering from oral candidiasis were investigated. Methods: A fungal suspension with a density of 3×10 8 CFU/ml was taken from the isolate of a case with acute vaginitis. In order to achieve a medicinal formulation, accurate twice the minimum inhibitory concentration (MIC) of SKJO and 10 times MIC of nystatin was used with 0.8% agar as a base material. In this study, 35 rats divided into 5 groups each of 7 were used. The assessment of level of infection and specification of the effects of treatment were performed using microbiological and histopathological methods as well as clinical examinations. Results: Our results show that carvacrol is the main compound of SKJ essential oil. Lesions completely disappeared in both treatment groups (SKJO and nystatin) after 8 days of treatment. Furthermore, in groups treated with SKJO and nystatin, the quantities of mean logarithm of colony forming unit (CFU) were 85.62% and 90.62%, respectively, in comparison with placebo group. Also, histopathological properties suggested no infection in groups who had clean and normal dorsal tongue mucosa. Conclusions: Using SKJO with twice accuracy it was concluded that MIC in immunosuppressed rats was quite successful in a time of a week and equal with that of a nystatin treatment with an accuracy of 10 times the MIC." @default.
- W2897843430 created "2018-10-26" @default.
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- W2897843430 date "2018-09-01" @default.
- W2897843430 modified "2023-09-26" @default.
- W2897843430 title "Antifungal effect of <i>Satureja khuzestanica</i> Jamzad essential oil on oral candidiasis in immunosuppressed rats" @default.
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- W2897843430 doi "https://doi.org/10.2478/hepo-2018-0017" @default.
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