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- W2897848520 abstract "Amoxicilin have a short residence time which is caused by the influence of gastric emptying. Floating drug delivery system as a resolve for amoxcicilin in combating bacterial Helicobacter pylory have been synthesized based on semi-IPN hydrogel chitosan-methyl cellulose containing pore forming agent (PFA) KHCO3 and K2CO3. Characterizations of the hydrogel were carried out by using Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectrophotometry, and stereo optical microscope. Overall, KHCO3 in hydrogels showed a faster floating lag time (12m 41s) than K2CO3 (14m 40s) and both have a floating time of more than 3 hours. Based on floating ability evaluation, the optimum composition of PFA in hydrogel was KHCO3 20%. The comparison results between optimum composition in this research and optimum composition from previous research (used PFA CaCO3 15%) with the same drug loading process (in situ) showed that KHCO3 in hydrogel have a higher encapsulation efficiency and more controlled drug release profile than CaCO3 in hydrogel, namely 79% & 72% for encapsulation efficiency of KHCO3 20% and CaCO3 15%, respectively. The comparison results of drug loading process with the same PFA in the in situ loading drug process showed a higher encapsulation efficiency and more controlled drug release profile than the post loading drug process." @default.
- W2897848520 created "2018-10-26" @default.
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- W2897848520 date "2018-01-01" @default.
- W2897848520 modified "2023-09-23" @default.
- W2897848520 title "Evaluation of pore forming agent effect and drug loading process on hydrogel semi-IPN chitosan-methyl cellulose in a floating drug delivery system" @default.
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- W2897848520 doi "https://doi.org/10.1063/1.5064055" @default.
- W2897848520 hasPublicationYear "2018" @default.
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