FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897850998> ?p ?o ?g. }

• W2897850998 endingPage "e12709" @default.
• W2897850998 startingPage "e12709" @default.
• W2897850998 abstract "Abstract Background: Several randomized controlled trials (RCTs) have been investigated the benefits of soluble guanylate cyclase (sGC) stimulators in the treatment of heart failure, but a comprehensive evaluation is lacking. We performed a meta-analysis to evaluate the efficacy and safety of oral sGC stimulators (vericiguat and riociguat) in patients with heart failure. Methods: Studies were searched and screened in PubMed, Embase, and Cochrane Library. Eligible RCTs were included that reported mortality, the change of EuroQol Group 5-Dmensional Self-report Questionnaire (EQ-5D) US index, N-terminal pro-B-type natriuretic peptide (NT-proBNP), or serious adverse events (SAEs). Relative risk or weight mean difference (WMD) was estimated using fixed effect model or random effect model. Analysis of sensitivity and publication bias was conducted. Results: Five trials with a total of 1200 patients were included. sGC stimulators had no impact on the mortality (1.25; 95% confidence interval 0.50–3.11) and significantly improved EQ-5D US index (0.04; 95% confidence interval 0.020–0.05). Furthermore, in comparison with control group, NT-proBNP was statistically decreased in riociguat group (−0.78; 95% confidence interval −1.01 to −0.47), but not in vericiguat group (0.04, 95% confidence interval −0.18 to 0.25). There were not obverse differences in SAEs between sGC stimulators and control groups (0.90; 95% confidence interval 0.72–1.12). Conclusion: Our meta-analysis suggests that sGC stimulators could improve the quality of life in patients with heart failure with good tolerance and safety, but their long-term benefits need to be observed in the future. sGC stimulators are likely to be promising add-on strategies for the treatment of heart failure." @default.
• W2897850998 created "2018-10-26" @default.
• W2897850998 creator A5001233601 @default.
• W2897850998 creator A5022381998 @default.
• W2897850998 creator A5024473069 @default.
• W2897850998 creator A5061055465 @default.
• W2897850998 date "2018-10-01" @default.
• W2897850998 modified "2023-09-26" @default.
• W2897850998 title "The efficacy and safety of soluble guanylate cyclase stimulators in patients with heart failure" @default.
• W2897850998 cites W1495415258 @default.
• W2897850998 cites W1549731978 @default.
• W2897850998 cites W1977589606 @default.
• W2897850998 cites W1984243104 @default.
• W2897850998 cites W1986367989 @default.
• W2897850998 cites W1990930862 @default.
• W2897850998 cites W2002106146 @default.
• W2897850998 cites W2005501262 @default.
• W2897850998 cites W2009428581 @default.
• W2897850998 cites W2012223673 @default.
• W2897850998 cites W2018688418 @default.
• W2897850998 cites W2028148874 @default.
• W2897850998 cites W2054935021 @default.
• W2897850998 cites W2076841438 @default.
• W2897850998 cites W2085987384 @default.
• W2897850998 cites W2096644655 @default.
• W2897850998 cites W2103614823 @default.
• W2897850998 cites W2104019772 @default.
• W2897850998 cites W2105296252 @default.
• W2897850998 cites W2105928696 @default.
• W2897850998 cites W2113439549 @default.
• W2897850998 cites W2113835063 @default.
• W2897850998 cites W2125353700 @default.
• W2897850998 cites W2132587013 @default.
• W2897850998 cites W2150319713 @default.
• W2897850998 cites W2164227851 @default.
• W2897850998 cites W2512054829 @default.
• W2897850998 cites W2515773670 @default.
• W2897850998 cites W2559196229 @default.
• W2897850998 cites W2603535098 @default.
• W2897850998 cites W2621450152 @default.
• W2897850998 cites W2761635900 @default.
• W2897850998 cites W2768901393 @default.
• W2897850998 doi "https://doi.org/10.1097/md.0000000000012709" @default.
• W2897850998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203591" @default.
• W2897850998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30313068" @default.
• W2897850998 hasPublicationYear "2018" @default.
• W2897850998 type Work @default.
• W2897850998 sameAs 2897850998 @default.
• W2897850998 citedByCount "10" @default.
• W2897850998 countsByYear W28978509982020 @default.
• W2897850998 countsByYear W28978509982021 @default.
• W2897850998 countsByYear W28978509982022 @default.
• W2897850998 crossrefType "journal-article" @default.
• W2897850998 hasAuthorship W2897850998A5001233601 @default.
• W2897850998 hasAuthorship W2897850998A5022381998 @default.
• W2897850998 hasAuthorship W2897850998A5024473069 @default.
• W2897850998 hasAuthorship W2897850998A5061055465 @default.
• W2897850998 hasBestOaLocation W28978509981 @default.
• W2897850998 hasConcept C126322002 @default.
• W2897850998 hasConcept C164705383 @default.
• W2897850998 hasConcept C168563851 @default.
• W2897850998 hasConcept C178853913 @default.
• W2897850998 hasConcept C197934379 @default.
• W2897850998 hasConcept C2775915353 @default.
• W2897850998 hasConcept C2776304953 @default.
• W2897850998 hasConcept C2776478404 @default.
• W2897850998 hasConcept C2777428986 @default.
• W2897850998 hasConcept C2778198053 @default.
• W2897850998 hasConcept C44249647 @default.
• W2897850998 hasConcept C71924100 @default.
• W2897850998 hasConcept C82789193 @default.
• W2897850998 hasConcept C95190672 @default.
• W2897850998 hasConceptScore W2897850998C126322002 @default.
• W2897850998 hasConceptScore W2897850998C164705383 @default.
• W2897850998 hasConceptScore W2897850998C168563851 @default.
• W2897850998 hasConceptScore W2897850998C178853913 @default.
• W2897850998 hasConceptScore W2897850998C197934379 @default.
• W2897850998 hasConceptScore W2897850998C2775915353 @default.
• W2897850998 hasConceptScore W2897850998C2776304953 @default.
• W2897850998 hasConceptScore W2897850998C2776478404 @default.
• W2897850998 hasConceptScore W2897850998C2777428986 @default.
• W2897850998 hasConceptScore W2897850998C2778198053 @default.
• W2897850998 hasConceptScore W2897850998C44249647 @default.
• W2897850998 hasConceptScore W2897850998C71924100 @default.
• W2897850998 hasConceptScore W2897850998C82789193 @default.
• W2897850998 hasConceptScore W2897850998C95190672 @default.
• W2897850998 hasIssue "41" @default.
• W2897850998 hasLocation W28978509981 @default.
• W2897850998 hasLocation W28978509982 @default.
• W2897850998 hasLocation W28978509983 @default.
• W2897850998 hasLocation W28978509984 @default.
• W2897850998 hasOpenAccess W2897850998 @default.
• W2897850998 hasPrimaryLocation W28978509981 @default.
• W2897850998 hasRelatedWork W2051712573 @default.
• W2897850998 hasRelatedWork W2217553306 @default.
• W2897850998 hasRelatedWork W2328354663 @default.
• W2897850998 hasRelatedWork W2381982637 @default.
• W2897850998 hasRelatedWork W2383671142 @default.

• next