Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897851454> ?p ?o ?g. }
- W2897851454 endingPage "e147" @default.
- W2897851454 startingPage "e143" @default.
- W2897851454 abstract "In 2018, WHO issued guidelines for the diagnosis, prevention, and management of HIV-related cryptococcal disease. Two strategies are recommended to reduce the high mortality associated with HIV-related cryptococcal meningitis in low-income and middle-income countries (LMICs): optimised combination therapies for confirmed meningitis cases and cryptococcal antigen screening programmes for ambulatory people living with HIV who access care. WHO's preferred therapy for the treatment of HIV-related cryptococcal meningitis in LMICs is 1 week of amphotericin B plus flucytosine, and the alternative therapy is 2 weeks of fluconazole plus flucytosine. In the ACTA trial, 1-week (short course) amphotericin B plus flucytosine resulted in a 10-week mortality of 24% (95% CI -16 to 32) and 2 weeks of fluconazole and flucytosine resulted in a 10-week mortality of 35% (95% CI -29 to 41). However, with widely used fluconazole monotherapy, mortality because of HIV-related cryptococcal meningitis is approximately 70% in many African LMIC settings. Therefore, the potential to transform the management of HIV-related cryptococcal meningitis in resource-limited settings is substantial. Sustainable access to essential medicines, including flucytosine and amphotericin B, in LMICs is paramount and the focus of this Personal View." @default.
- W2897851454 created "2018-10-26" @default.
- W2897851454 creator A5004245087 @default.
- W2897851454 creator A5004507608 @default.
- W2897851454 creator A5007007569 @default.
- W2897851454 creator A5008729040 @default.
- W2897851454 creator A5009781874 @default.
- W2897851454 creator A5011692109 @default.
- W2897851454 creator A5011896764 @default.
- W2897851454 creator A5012480739 @default.
- W2897851454 creator A5013575025 @default.
- W2897851454 creator A5014418781 @default.
- W2897851454 creator A5014601631 @default.
- W2897851454 creator A5015158507 @default.
- W2897851454 creator A5016834421 @default.
- W2897851454 creator A5021500380 @default.
- W2897851454 creator A5022169135 @default.
- W2897851454 creator A5023629460 @default.
- W2897851454 creator A5026484637 @default.
- W2897851454 creator A5027142325 @default.
- W2897851454 creator A5027410574 @default.
- W2897851454 creator A5028022459 @default.
- W2897851454 creator A5029589850 @default.
- W2897851454 creator A5030670576 @default.
- W2897851454 creator A5031523165 @default.
- W2897851454 creator A5032321599 @default.
- W2897851454 creator A5033751029 @default.
- W2897851454 creator A5034898456 @default.
- W2897851454 creator A5037592415 @default.
- W2897851454 creator A5038084550 @default.
- W2897851454 creator A5039991713 @default.
- W2897851454 creator A5041069033 @default.
- W2897851454 creator A5041793241 @default.
- W2897851454 creator A5043245285 @default.
- W2897851454 creator A5044658844 @default.
- W2897851454 creator A5046188552 @default.
- W2897851454 creator A5047459993 @default.
- W2897851454 creator A5049351239 @default.
- W2897851454 creator A5049967943 @default.
- W2897851454 creator A5057941110 @default.
- W2897851454 creator A5058617930 @default.
- W2897851454 creator A5059641375 @default.
- W2897851454 creator A5059831856 @default.
- W2897851454 creator A5060071132 @default.
- W2897851454 creator A5061027575 @default.
- W2897851454 creator A5067026202 @default.
- W2897851454 creator A5069610196 @default.
- W2897851454 creator A5069690890 @default.
- W2897851454 creator A5075290322 @default.
- W2897851454 creator A5076050780 @default.
- W2897851454 creator A5076060339 @default.
- W2897851454 creator A5080387613 @default.
- W2897851454 creator A5081058602 @default.
- W2897851454 creator A5083752740 @default.
- W2897851454 creator A5085389475 @default.
- W2897851454 creator A5089661785 @default.
- W2897851454 creator A5091442849 @default.
- W2897851454 date "2019-04-01" @default.
- W2897851454 modified "2023-10-10" @default.
- W2897851454 title "Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries" @default.
- W2897851454 cites W2030000278 @default.
- W2897851454 cites W2034630867 @default.
- W2897851454 cites W2096006098 @default.
- W2897851454 cites W2108521877 @default.
- W2897851454 cites W2125695159 @default.
- W2897851454 cites W2133750516 @default.
- W2897851454 cites W2135177684 @default.
- W2897851454 cites W2146391063 @default.
- W2897851454 cites W2164307384 @default.
- W2897851454 cites W2173389442 @default.
- W2897851454 cites W2227875810 @default.
- W2897851454 cites W2294119443 @default.
- W2897851454 cites W2611697423 @default.
- W2897851454 cites W2613372787 @default.
- W2897851454 cites W2734648766 @default.
- W2897851454 cites W2763181211 @default.
- W2897851454 cites W2790367178 @default.
- W2897851454 cites W2790980679 @default.
- W2897851454 cites W2791888954 @default.
- W2897851454 doi "https://doi.org/10.1016/s1473-3099(18)30493-6" @default.
- W2897851454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30344084" @default.
- W2897851454 hasPublicationYear "2019" @default.
- W2897851454 type Work @default.
- W2897851454 sameAs 2897851454 @default.
- W2897851454 citedByCount "54" @default.
- W2897851454 countsByYear W28978514542018 @default.
- W2897851454 countsByYear W28978514542019 @default.
- W2897851454 countsByYear W28978514542020 @default.
- W2897851454 countsByYear W28978514542021 @default.
- W2897851454 countsByYear W28978514542022 @default.
- W2897851454 countsByYear W28978514542023 @default.
- W2897851454 crossrefType "journal-article" @default.
- W2897851454 hasAuthorship W2897851454A5004245087 @default.
- W2897851454 hasAuthorship W2897851454A5004507608 @default.
- W2897851454 hasAuthorship W2897851454A5007007569 @default.
- W2897851454 hasAuthorship W2897851454A5008729040 @default.
- W2897851454 hasAuthorship W2897851454A5009781874 @default.
- W2897851454 hasAuthorship W2897851454A5011692109 @default.