FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897851930> ?p ?o ?g. }

• W2897851930 abstract "ABSTRACT Secondary structure is a fundamental feature for both noncoding and messenger RNA. However, our understandings about the secondary structure of mRNA, especially for the coding regions, remain elusive, likely due to translation and the lack of RNA binding proteins that sustain the consensus structure, such as those bind to noncoding RNA. Indeed, mRNA has recently been found to bear pervasive alternative structures, whose overall evolutionary and functional significance remained untested. We hereby approached this problem by estimating folding specificity, the probability that a fragment of RNA folds back to the same partner once re-folded. We showed that folding specificity for mRNA is lower than noncoding RNA, and displays moderate evolutionary conservation between orthologs and between paralogs. More importantly, we found that specific rather than alternative folding is more likely evolutionarily adaptive, since it is more frequently associated with functionally important genes or sites within a gene. Additional analysis in combination with ribosome density suggests the capability of modulating ribosome movement as one potential functional advantage provided by specific folding. Our findings revealed a novel facet of RNA structome with important functional and evolutionary implications, and points to a potential way of disentangling mRNA secondary structures maintained by natural selection from molecular noise." @default.
• W2897851930 created "2018-10-26" @default.
• W2897851930 creator A5019029226 @default.
• W2897851930 creator A5027264371 @default.
• W2897851930 creator A5046016744 @default.
• W2897851930 creator A5070725998 @default.
• W2897851930 date "2018-10-11" @default.
• W2897851930 modified "2023-09-23" @default.
• W2897851930 title "Specificity of RNA folding and its association with evolutionarily adaptive mRNA secondary structure" @default.
• W2897851930 cites W1415011740 @default.
• W2897851930 cites W1511465838 @default.
• W2897851930 cites W1515226261 @default.
• W2897851930 cites W1955207250 @default.
• W2897851930 cites W1969274403 @default.
• W2897851930 cites W1970764623 @default.
• W2897851930 cites W1970827552 @default.
• W2897851930 cites W1971218796 @default.
• W2897851930 cites W19715912 @default.
• W2897851930 cites W1974736226 @default.
• W2897851930 cites W1979328799 @default.
• W2897851930 cites W1980900189 @default.
• W2897851930 cites W1984224524 @default.
• W2897851930 cites W1984708728 @default.
• W2897851930 cites W1984795507 @default.
• W2897851930 cites W1985368446 @default.
• W2897851930 cites W1986007760 @default.
• W2897851930 cites W1986067700 @default.
• W2897851930 cites W1989263240 @default.
• W2897851930 cites W1992927069 @default.
• W2897851930 cites W2003993220 @default.
• W2897851930 cites W2013125330 @default.
• W2897851930 cites W2016779764 @default.
• W2897851930 cites W2019337061 @default.
• W2897851930 cites W2023515240 @default.
• W2897851930 cites W2025569664 @default.
• W2897851930 cites W2028989453 @default.
• W2897851930 cites W2032575686 @default.
• W2897851930 cites W2034768847 @default.
• W2897851930 cites W2036573675 @default.
• W2897851930 cites W2038598202 @default.
• W2897851930 cites W2039790548 @default.
• W2897851930 cites W2046335009 @default.
• W2897851930 cites W2049595315 @default.
• W2897851930 cites W2051242197 @default.
• W2897851930 cites W2056230513 @default.
• W2897851930 cites W2058864686 @default.
• W2897851930 cites W2059079617 @default.
• W2897851930 cites W2060421156 @default.
• W2897851930 cites W2060718478 @default.
• W2897851930 cites W2060909469 @default.
• W2897851930 cites W2064664075 @default.
• W2897851930 cites W2071849521 @default.
• W2897851930 cites W2076091642 @default.
• W2897851930 cites W2083014488 @default.
• W2897851930 cites W2084875499 @default.
• W2897851930 cites W2086471971 @default.
• W2897851930 cites W2087903164 @default.
• W2897851930 cites W2089115165 @default.
• W2897851930 cites W2094507358 @default.
• W2897851930 cites W2107086008 @default.
• W2897851930 cites W2110335151 @default.
• W2897851930 cites W2113234327 @default.
• W2897851930 cites W2113506612 @default.
• W2897851930 cites W2114431705 @default.
• W2897851930 cites W2115585439 @default.
• W2897851930 cites W2115787060 @default.
• W2897851930 cites W2115920327 @default.
• W2897851930 cites W2118258530 @default.
• W2897851930 cites W2122611378 @default.
• W2897851930 cites W2123742352 @default.
• W2897851930 cites W2124565600 @default.
• W2897851930 cites W2125615424 @default.
• W2897851930 cites W2129178024 @default.
• W2897851930 cites W2138309685 @default.
• W2897851930 cites W2140127479 @default.
• W2897851930 cites W2142165994 @default.
• W2897851930 cites W2146564033 @default.
• W2897851930 cites W2147411714 @default.
• W2897851930 cites W2148575508 @default.
• W2897851930 cites W2149785901 @default.
• W2897851930 cites W2151102421 @default.
• W2897851930 cites W2160876388 @default.
• W2897851930 cites W2162401753 @default.
• W2897851930 cites W2163951588 @default.
• W2897851930 cites W2164232580 @default.
• W2897851930 cites W2167858459 @default.
• W2897851930 cites W2169456326 @default.
• W2897851930 cites W2170675417 @default.
• W2897851930 cites W2233915997 @default.
• W2897851930 cites W2339766289 @default.
• W2897851930 cites W2346311008 @default.
• W2897851930 cites W2363081453 @default.
• W2897851930 cites W2388201280 @default.
• W2897851930 cites W2415845301 @default.
• W2897851930 cites W2474522537 @default.
• W2897851930 cites W2495368390 @default.
• W2897851930 cites W2501900207 @default.
• W2897851930 cites W2583817197 @default.
• W2897851930 cites W2585997027 @default.
• W2897851930 cites W2591974314 @default.

• next