FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897856711> ?p ?o ?g. }

• W2897856711 endingPage "482" @default.
• W2897856711 startingPage "474" @default.
• W2897856711 abstract "Background Observational studies suggest that some patients meeting criteria for ARDS no longer fulfill the oxygenation criterion early in the course of their illness. This subphenotype of rapidly improving ARDS has not been well characterized. We attempted to assess the prevalence, characteristics, and outcomes of rapidly improving ARDS and to identify which variables are useful to predict it. Methods A secondary analysis was performed of patient level data from six ARDS Network randomized controlled trials. We defined rapidly improving ARDS, contrasted with ARDS > 1 day, as extubation or a Pao2 to Fio2 ratio (Pao2:Fio2) > 300 on the first study day following enrollment. Results The prevalence of rapidly improving ARDS was 10.5% (458 of 4,361 patients) and increased over time. Of the 1,909 patients enrolled in the three most recently published trials, 197 (10.3%) were extubated on the first study day, and 265 (13.9%) in total had rapidly improving ARDS. Patients with rapidly improving ARDS had lower baseline severity of illness and lower 60-day mortality (10.2% vs 26.3%; P   1 day. Pao2:Fio2 at screening, change in Pao2:Fio2 from screening to enrollment, use of vasopressor agents, Fio2 at enrollment, and serum bilirubin levels were useful predictive variables. Conclusions Rapidly improving ARDS, mostly defined by early extubation, is an increasingly prevalent and distinct subphenotype, associated with better outcomes than ARDS > 1 day. Enrollment of patients with rapidly improving ARDS may negatively affect the prognostic enrichment and contribute to the failure of therapeutic trials." @default.
• W2897856711 created "2018-10-26" @default.
• W2897856711 creator A5010710591 @default.
• W2897856711 creator A5012880037 @default.
• W2897856711 creator A5028298831 @default.
• W2897856711 creator A5037201308 @default.
• W2897856711 creator A5076060274 @default.
• W2897856711 creator A5086644778 @default.
• W2897856711 date "2019-03-01" @default.
• W2897856711 modified "2023-10-17" @default.
• W2897856711 title "Rapidly Improving ARDS in Therapeutic Randomized Controlled Trials" @default.
• W2897856711 cites W1989539384 @default.
• W2897856711 cites W2011876852 @default.
• W2897856711 cites W2012015791 @default.
• W2897856711 cites W2012475675 @default.
• W2897856711 cites W2083412037 @default.
• W2897856711 cites W2102501066 @default.
• W2897856711 cites W2106923828 @default.
• W2897856711 cites W2110379870 @default.
• W2897856711 cites W2117904404 @default.
• W2897856711 cites W2121517569 @default.
• W2897856711 cites W2124519382 @default.
• W2897856711 cites W2138928595 @default.
• W2897856711 cites W2161328469 @default.
• W2897856711 cites W2283987856 @default.
• W2897856711 cites W2286228001 @default.
• W2897856711 cites W2320873518 @default.
• W2897856711 cites W2322392387 @default.
• W2897856711 cites W2323686926 @default.
• W2897856711 cites W2341839134 @default.
• W2897856711 cites W2370339191 @default.
• W2897856711 cites W2461875524 @default.
• W2897856711 cites W2496057903 @default.
• W2897856711 cites W2590588347 @default.
• W2897856711 cites W2597070792 @default.
• W2897856711 cites W2600848530 @default.
• W2897856711 cites W2602748438 @default.
• W2897856711 cites W2610582798 @default.
• W2897856711 cites W2616747684 @default.
• W2897856711 cites W2618861551 @default.
• W2897856711 cites W2626627673 @default.
• W2897856711 cites W2774525674 @default.
• W2897856711 cites W2789230233 @default.
• W2897856711 cites W2790436077 @default.
• W2897856711 cites W2797453375 @default.
• W2897856711 cites W2800245949 @default.
• W2897856711 cites W2807482332 @default.
• W2897856711 doi "https://doi.org/10.1016/j.chest.2018.09.031" @default.
• W2897856711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6414787" @default.
• W2897856711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359616" @default.
• W2897856711 hasPublicationYear "2019" @default.
• W2897856711 type Work @default.
• W2897856711 sameAs 2897856711 @default.
• W2897856711 citedByCount "55" @default.
• W2897856711 countsByYear W28978567112019 @default.
• W2897856711 countsByYear W28978567112020 @default.
• W2897856711 countsByYear W28978567112021 @default.
• W2897856711 countsByYear W28978567112022 @default.
• W2897856711 countsByYear W28978567112023 @default.
• W2897856711 crossrefType "journal-article" @default.
• W2897856711 hasAuthorship W2897856711A5010710591 @default.
• W2897856711 hasAuthorship W2897856711A5012880037 @default.
• W2897856711 hasAuthorship W2897856711A5028298831 @default.
• W2897856711 hasAuthorship W2897856711A5037201308 @default.
• W2897856711 hasAuthorship W2897856711A5076060274 @default.
• W2897856711 hasAuthorship W2897856711A5086644778 @default.
• W2897856711 hasBestOaLocation W28978567112 @default.
• W2897856711 hasConcept C126322002 @default.
• W2897856711 hasConcept C168563851 @default.
• W2897856711 hasConcept C177713679 @default.
• W2897856711 hasConcept C2776348555 @default.
• W2897856711 hasConcept C2777714996 @default.
• W2897856711 hasConcept C71924100 @default.
• W2897856711 hasConceptScore W2897856711C126322002 @default.
• W2897856711 hasConceptScore W2897856711C168563851 @default.
• W2897856711 hasConceptScore W2897856711C177713679 @default.
• W2897856711 hasConceptScore W2897856711C2776348555 @default.
• W2897856711 hasConceptScore W2897856711C2777714996 @default.
• W2897856711 hasConceptScore W2897856711C71924100 @default.
• W2897856711 hasFunder F4320332161 @default.
• W2897856711 hasIssue "3" @default.
• W2897856711 hasLocation W28978567111 @default.
• W2897856711 hasLocation W28978567112 @default.
• W2897856711 hasLocation W28978567113 @default.
• W2897856711 hasOpenAccess W2897856711 @default.
• W2897856711 hasPrimaryLocation W28978567111 @default.
• W2897856711 hasRelatedWork W2360016312 @default.
• W2897856711 hasRelatedWork W2507295142 @default.
• W2897856711 hasRelatedWork W2739819551 @default.
• W2897856711 hasRelatedWork W2775826613 @default.
• W2897856711 hasRelatedWork W3116297196 @default.
• W2897856711 hasRelatedWork W3137102546 @default.
• W2897856711 hasRelatedWork W3159250744 @default.
• W2897856711 hasRelatedWork W4288358222 @default.
• W2897856711 hasRelatedWork W4214780115 @default.
• W2897856711 hasRelatedWork W4214954803 @default.
• W2897856711 hasVolume "155" @default.
• W2897856711 isParatext "false" @default.

• next