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- W2897859321 endingPage "152" @default.
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- W2897859321 abstract "Nutrient handling by higher organisms is a complex process that is regulated at the transcriptional level. Studies over the past 15 years have highlighted the critical importance of a family of transcriptional regulators termed the Krüppel-like factors (KLFs) in metabolism. Within an organ, distinct KLFs direct networks of metabolic gene targets to achieve specialized functions. This regulation is often orchestrated in concert with recruitment of tissue-specific transcriptional regulators, particularly members of the nuclear receptor family. Upon nutrient entry into the intestine, gut, and liver, KLFs control a range of functions from bile synthesis to intestinal stem cell maintenance to effect nutrient acquisition. Subsequently, coordinated KLF activity across multiple organs distributes nutrients to sites of storage or liberates them for use in response to changes in nutrient status. Finally, in energy-consuming organs like cardiac and skeletal muscle, KLFs tune local metabolic programs to precisely match substrate uptake, flux, and use, particularly via mitochondrial function, with energetic demand; this is achieved in part via circulating mediators, including glucocorticoids and insulin. Here, we summarize current understanding of KLFs in regulation of nutrient absorption, interorgan circulation, and tissue-specific use." @default.
- W2897859321 created "2018-10-26" @default.
- W2897859321 creator A5003863511 @default.
- W2897859321 creator A5013445622 @default.
- W2897859321 creator A5072888740 @default.
- W2897859321 creator A5084258827 @default.
- W2897859321 date "2018-10-10" @default.
- W2897859321 modified "2023-10-14" @default.
- W2897859321 title "The Krüppel-Like Factors and Control of Energy Homeostasis" @default.
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