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- W2897859327 abstract "Background: The hypocellular variant of acute myeloid leukemia accounts for less than 10% of adult acute myeloid leukemia. The treatment of hypocellular acute myeloid leukemia remains unclear in the literature. This study aims to reveal the clinical outcome of hypocellular acute myeloid leukemia and the effect of treatment with azacitidine. Design and Methods:We retrospectively analyzed 13 cases reported to be hypocellular acute myeloid leukemia receiving treatment between 2011 and 2017. Results: The median age at diagnosis was 75 years old (range, 36-80). The median length of follow up was 425 days (range, 163-903) for censored patients. Two years overall survival (OS) rate was 37% in all patients. As initial treatment, 9 patients (69%) received conventional chemotherapy regimen (CCR group), 4 patients (31%) received azacitidine (Aza group). 3 patients (33%) reached CR in CCR group. No patient reached CR in Aza group, but 2 patients (50%) reached hematological improvement in Aza group. Median OS was 333 days in CCR group, 697 days in Aza group, respectively (p = 0.31). Median hospitalization days per month was 14.5 days (range, 2.35-30) in CCR group, 8.85 days (range, 0.7-15) in Aza group, respectively(p = 0.18). Median medical costs per month was 1,396,280 JPY (range, 641,780-2,502,650) in CCR group, 832,330 JPY (range, 267,410-1,173,050) in Aza group, respectively (p = 0.09). Conclusion: Our single center retrospective analysis indicated no significant difference in the effect between CCR group and Aza group. However we suggested azacitidine may shorten hospitalization and reduce medical costs than conventional chemotherapy without shortening the survival." @default.
- W2897859327 created "2018-10-26" @default.
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- W2897859327 date "2018-10-01" @default.
- W2897859327 modified "2023-09-30" @default.
- W2897859327 title "Retrospective analysis of the clinical outcome of hypocellular acute myeloid leukemia in a single institution" @default.
- W2897859327 doi "https://doi.org/10.1093/annonc/mdy375.010" @default.
- W2897859327 hasPublicationYear "2018" @default.
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