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- W2897860157 abstract "According to the network-based neurodegeneration theory, Alzheimer's disease (AD) is thought to target the large-scale brain network. The advent of positron emission tomography (PET) has enabled the in vivo visualization of tau and amyloid retention. In this study, we recruited cognitive normal (CN) subjects (8 normal control and 27 subjective memory impairment subjects), 71 amnestic mild cognitive impairment (aMCI) patients, 26 AD patients with T1-weighted brain magnetic resonance imaging (MRI), amyloid PET (18F-florbetaben) and tau PET (18F-THK5351). Through regional standardized uptake value ratios (SUVR) of PET images and cortical thickness across the 68 brain regions, we investigated cortical spreading patterns of amyloid retention, tau retention and cortical atrophy by sorting the regional frequencies of involvement. We then constructed relation networks among tau, amyloid and cortical atrophy using Pearson's correlation. Relation network between amyloid and tau retentions had hub nodes such as the banks of the superior temporal sulcus and lateral occipital regions. Also, the amyloid burden in precuneus and superior frontal regions revealed relation with cortical atrophy. In contrast, the tau retention in the frontal lobe and precuneus was associates with cortical atrophy." @default.
- W2897860157 created "2018-10-26" @default.
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- W2897860157 date "2018-07-01" @default.
- W2897860157 modified "2023-09-26" @default.
- W2897860157 title "P2‐359: RELATION NETWORKS OF NEURODEGENERATION IN ALZHEIMER'S DISEASE SPECTRUM: TAU, AMYLOID, AND CORTICAL ATROPHY" @default.
- W2897860157 doi "https://doi.org/10.1016/j.jalz.2018.06.1050" @default.
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