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- W2897865911 abstract "Abstract Cognitive control and decision-making relies on the interplay of medial and lateral prefrontal cortex (mPFC/LPFC), particularly for circumstances in which correct behavior requires integrating and selecting among multiple sources of interrelated information. While the interaction between mPFC and LPFC is generally acknowledged as a crucial circuit in adaptive behavior, the nature of this interaction remains open to debate, with various proposals suggesting complementary roles in ( i ) signaling the need for and implementing control, ( ii ) identifying and selecting appropriate behavioral policies from a candidate set, and ( iii ) constructing behavioral schemata for performance of structured tasks. Although these proposed roles capture salient aspects of conjoint mPFC/LPFC function, none are sufficiently well-specified to provide a detailed account of the continuous interaction of the two regions during ongoing behavior. A recent computational model of mPFC and LPFC, the Hierarchical Error Representation (HER) model, places the regions within the framework of hierarchical predictive coding, and suggests how they interact during behavioral periods preceding and following salient events. In this manuscript, we extend the HER model to incorporate real-time temporal dynamics and demonstrate how the extended model is able to capture single-unit neurophysiological, behavioral, and network effects previously reported in the literature. Our results add to the wide range of results that can be accounted for by the HER model, and provide further evidence for predictive coding as a unifying framework for understanding PFC function and organization." @default.
- W2897865911 created "2018-10-26" @default.
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- W2897865911 date "2018-10-10" @default.
- W2897865911 modified "2023-09-23" @default.
- W2897865911 title "Interactions of medial and lateral prefrontal cortex in hierarchical predictive coding" @default.
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- W2897865911 doi "https://doi.org/10.1101/439927" @default.
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