Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897867064> ?p ?o ?g. }
- W2897867064 endingPage "2373" @default.
- W2897867064 startingPage "2364" @default.
- W2897867064 abstract "Changes in brain metabolism are a hallmark of alcohol use disorder (AUD). Determining how AUD changes the brain proteome is critical for understanding the effects of alcohol consumption on biochemical processes in the brain. We used data-independent acquisition mass spectrometry proteomics to study differences in the abundance of proteins associated with AUD in prefrontal lobe and motor cortex from autopsy brain. AUD had a substantial effect on the overall brain proteome exceeding the inherent differences between brain regions. Proteins associated with glycolysis, trafficking, the cytoskeleton, and excitotoxicity were altered in abundance in AUD. We observed extensive changes in the abundance of key metabolic enzymes, consistent with a switch from glucose to acetate utilization in the AUD brain. We propose that metabolic adaptations allowing efficient acetate utilization contribute to ethanol dependence in AUD." @default.
- W2897867064 created "2018-10-26" @default.
- W2897867064 creator A5026257435 @default.
- W2897867064 creator A5031381367 @default.
- W2897867064 creator A5049849829 @default.
- W2897867064 creator A5075570090 @default.
- W2897867064 creator A5080285308 @default.
- W2897867064 creator A5087530786 @default.
- W2897867064 date "2019-02-26" @default.
- W2897867064 modified "2023-10-06" @default.
- W2897867064 title "Proteomics Reveals Profound Metabolic Changes in the Alcohol Use Disorder Brain" @default.
- W2897867064 cites W1523775339 @default.
- W2897867064 cites W1531285870 @default.
- W2897867064 cites W1568041104 @default.
- W2897867064 cites W1943043182 @default.
- W2897867064 cites W1972032978 @default.
- W2897867064 cites W1980835881 @default.
- W2897867064 cites W1984387620 @default.
- W2897867064 cites W1986776839 @default.
- W2897867064 cites W1992296468 @default.
- W2897867064 cites W1992902970 @default.
- W2897867064 cites W1995492336 @default.
- W2897867064 cites W1996039145 @default.
- W2897867064 cites W1999685134 @default.
- W2897867064 cites W2000853431 @default.
- W2897867064 cites W2007273192 @default.
- W2897867064 cites W2031087027 @default.
- W2897867064 cites W2032522648 @default.
- W2897867064 cites W2032755399 @default.
- W2897867064 cites W2034391317 @default.
- W2897867064 cites W2044104531 @default.
- W2897867064 cites W2052338190 @default.
- W2897867064 cites W2065358038 @default.
- W2897867064 cites W2070004275 @default.
- W2897867064 cites W2070601362 @default.
- W2897867064 cites W2076480502 @default.
- W2897867064 cites W2088417711 @default.
- W2897867064 cites W2096173332 @default.
- W2897867064 cites W2097948853 @default.
- W2897867064 cites W2098048169 @default.
- W2897867064 cites W2102366629 @default.
- W2897867064 cites W2105665255 @default.
- W2897867064 cites W2105952206 @default.
- W2897867064 cites W2110337011 @default.
- W2897867064 cites W2112929255 @default.
- W2897867064 cites W2114165700 @default.
- W2897867064 cites W2115155255 @default.
- W2897867064 cites W2118937212 @default.
- W2897867064 cites W2121884198 @default.
- W2897867064 cites W2126926134 @default.
- W2897867064 cites W2133465414 @default.
- W2897867064 cites W2135581618 @default.
- W2897867064 cites W2141248073 @default.
- W2897867064 cites W2151031844 @default.
- W2897867064 cites W2158217645 @default.
- W2897867064 cites W2159675211 @default.
- W2897867064 cites W2164435682 @default.
- W2897867064 cites W2165906907 @default.
- W2897867064 cites W2169222170 @default.
- W2897867064 cites W2172128771 @default.
- W2897867064 cites W2212369426 @default.
- W2897867064 cites W2336846619 @default.
- W2897867064 cites W2340761255 @default.
- W2897867064 cites W2537623931 @default.
- W2897867064 cites W2565464415 @default.
- W2897867064 cites W2594274697 @default.
- W2897867064 cites W2595425890 @default.
- W2897867064 cites W2755654621 @default.
- W2897867064 cites W2766486392 @default.
- W2897867064 cites W2781920423 @default.
- W2897867064 cites W2789372763 @default.
- W2897867064 cites W2790467391 @default.
- W2897867064 cites W2790535666 @default.
- W2897867064 cites W2805016230 @default.
- W2897867064 cites W2897149322 @default.
- W2897867064 cites W41879369 @default.
- W2897867064 cites W4230119926 @default.
- W2897867064 cites W4231376406 @default.
- W2897867064 doi "https://doi.org/10.1021/acschemneuro.8b00660" @default.
- W2897867064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30807102" @default.
- W2897867064 hasPublicationYear "2019" @default.
- W2897867064 type Work @default.
- W2897867064 sameAs 2897867064 @default.
- W2897867064 citedByCount "24" @default.
- W2897867064 countsByYear W28978670642019 @default.
- W2897867064 countsByYear W28978670642020 @default.
- W2897867064 countsByYear W28978670642021 @default.
- W2897867064 countsByYear W28978670642022 @default.
- W2897867064 countsByYear W28978670642023 @default.
- W2897867064 crossrefType "journal-article" @default.
- W2897867064 hasAuthorship W2897867064A5026257435 @default.
- W2897867064 hasAuthorship W2897867064A5031381367 @default.
- W2897867064 hasAuthorship W2897867064A5049849829 @default.
- W2897867064 hasAuthorship W2897867064A5075570090 @default.
- W2897867064 hasAuthorship W2897867064A5080285308 @default.
- W2897867064 hasAuthorship W2897867064A5087530786 @default.
- W2897867064 hasBestOaLocation W28978670642 @default.
- W2897867064 hasConcept C104317684 @default.