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- W2897870525 abstract "The goal of this study was to examine cognitive aging-associated pathophysiology (i.e., amyloid deposition and glucose metabolism) between Supernormals (SN) and older adults with normal cognition (NC), amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Subjects from the ADNI database were included if they received T1-weighted MRI, amyloid PET, FDG-PET, and cognitive testing within a 6 month period. PET Standardized uptake value ratios (SUVrs) were calculated for the whole cortex and 68 regions of interest, with whole cerebellum serving as reference. SNs had significantly lower whole cortex amyloid burden than aMCI and AD groups, and significantly higher glucose metabolism than all other groups. Regional analysis revealed that amyloid burden and glucose metabolism in the right isthmus cingulate cortex significantly differed in SN compared to others, while SN also significantly differed from others in glucose metabolism in several frontal and temporal regions. When considering the effect of amyloid burden, higher glucose metabolism was related to higher memory performance in NC, while the SN group maintained high-level memory performance regardless of the level of glucose metabolism. Preserved whole cortex glucose metabolism, as well as resistance to amyloidosis and glucose hypometabolism in the right isthmus cingulate cortex, contributes to the Supernormal phenomenon. These findings may be informative for the development of early screening biomarkers and therapeutic targets for modification of cognitive trajectories in the face of cognitive aging-associated pathophysiology." @default.
- W2897870525 created "2018-10-26" @default.
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- W2897870525 date "2018-07-01" @default.
- W2897870525 modified "2023-10-16" @default.
- W2897870525 title "P1‐404: AMYLOID AND FDG‐PET IMAGING OF SUCCESSFUL COGNITIVE AGING SHOW CHANGES IN GLOBAL CORTICAL GLUCOSE METABOLISM AND CINGULATE‐SPECIFIC AMYLOID DEPOSITION" @default.
- W2897870525 doi "https://doi.org/10.1016/j.jalz.2018.06.413" @default.
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