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- W2897870886 abstract "Carnosine is an endogenous dipeptide in vertebrates, and anserine is a natural derivative of carnosine. Anserine/carnosine supplementation (ACS) is reported to help preserve cognitive function in normal cognition elderly people. In the present trial, we investigated the effect of ACS on the prevention of AD in MCI subjects with or without APOE4. A double-blind, placebo-controlled 12-week trial was performed, in which subjects with MCI were randomized to take orally 750 mg of anserine and 250 mg of carnosine per day (active group) or a placebo (placebo group). Data were analyzed from 50 MCI subjects with a mean age of 72.8 years. Prevention of AD was assessed by Clinical Dementia Rating (CDR), as well as clinical evaluation. Data from psychological test butteries were also collected and analyzed. The change in CDR was −0.12±0.22 in the active group and -0.02±0.18 in the placebo group (p=0.0231). The number of patients clinically diagnosed as AD at follow-up in placebo group was 4, but 0 in active group (p=0.0371). Very importantly, in APOE4-positive subjects, we detected significant difference in the change of CDR score between the two groups (p=0.0261; −0.25±0.27 (active group) and 0±0.21 (placebo group)). In APOE4-negative subjects, there was no significant difference between the two groups. Oral ACS may protect against the onset of AD in Patients with Mild Cognitive Impairment, especially patients with the APOE4 allele." @default.
- W2897870886 created "2018-10-26" @default.
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- W2897870886 date "2018-07-01" @default.
- W2897870886 modified "2023-10-16" @default.
- W2897870886 title "P4‐190: EFFECT OF ANSERINE/CARNOSINE SUPPLEMENTATION ON THE PREVENTION OF ALZHEIMER'S DISEASE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT" @default.
- W2897870886 doi "https://doi.org/10.1016/j.jalz.2018.06.2595" @default.
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