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- W2897873107 abstract "Subjective cognitive impairment (SCI) is associated with the pre-clinical stage of Alzheimer's disease (AD) in the presence of positive biomarkers. By definition an SCI diagnosis necessitates no objective memory loss and available evidence suggests that the accumulating brain amyloid load in the pre-clinical stage does not correlate with the memory performance. The results that will be presented here are part of a still ongoing research project. Currently, we have 21 individuals diagnosed with SCI and whose CSF biomarker data is available. All participants underwent an extended procedure involving neurological examination, multimodal neuroimaging, neuropsychological assessment, and lumbar puncture for CSF biomarkers. Free and Cued Selective Reminding Test (FCSRT) was used as the principal measure to assess memory performance. The FCSRT is specifically recommended by the International Work Group who recently proposed a new diagnostic criteria for AD in order to document the AD-type memory loss. The age range was 40-69 years. The CSF Aβ concentration of the sample ranged between 352 and 1357 pg/mL. A Spearman correlation analysis revealed no correlations between the CSF Aβ levels and any of the FCSRT indices (free recall, delayed recall and cue index). Then based on their Aβ concentration, we assigned the sample into two groups: low Aβ group (n=14) and high Aβ group (n=13). The cutoff value was taken as 740 pg/mL. The two groups did not differ from each other with regard to age, years of education, and gender (p >.05). Then, a series of Mann Whitney U tests were used to compare the groups with regard to their above mentioned three FCSRT scores with Mann Whitney U test. None of the intergroup comparisons reached statistical significance (p >.05) Our initial findings are in line with the available evidence showing that cerebral amyloid deposition does not interfere with the memory performance as reflected by the traditional memory instruments." @default.
- W2897873107 created "2018-10-26" @default.
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- W2897873107 date "2018-07-01" @default.
- W2897873107 modified "2023-10-17" @default.
- W2897873107 title "P2‐229: THE EFFECT OF CSF AMYLOID BETA CONCENTRATIONS ON MEMORY PERFORMANCE OF THE INDIVIDUALS WITH SUBJECTIVE COGNITIVE IMPAIRMENT" @default.
- W2897873107 doi "https://doi.org/10.1016/j.jalz.2018.06.916" @default.
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