Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897874540> ?p ?o ?g. }
- W2897874540 endingPage "21" @default.
- W2897874540 startingPage "10" @default.
- W2897874540 abstract "Forkhead box transcription factor 3 (FOXP3) plays a pivotal role in the suppressive function of regulatory T cells. In addition to mRNA levels, FOXP3 activity can also be controlled by posttranslational mechanisms, which have not been studied in a comprehensive manner. Through extensive screening using selective inhibitors, we demonstrate that the inhibition of type I protein arginine methytransferases (PRMTs) attenuates the suppressive functions of regulatory T cells. FOXP3 undergoes methylation on arginine residues at positions 48 and 51 by interacting with protein arginine methyltransferase 1 (PRMT1). The inhibition of arginine methylation confers gene expression profiles representing type I helper T cells to FOXP3+ T cells, which results in attenuated suppressive activity. A methylation-defective mutant of FOXP3 displays less potent activity to suppress xenogeneic graft-versus-host disease in vivo. These results elucidate an important role of arginine methylation to enhance FOXP3 functions and are potentially applicable to modulate regulatory T cell functions." @default.
- W2897874540 created "2018-10-26" @default.
- W2897874540 creator A5005020998 @default.
- W2897874540 creator A5008158683 @default.
- W2897874540 creator A5012117525 @default.
- W2897874540 creator A5012467959 @default.
- W2897874540 creator A5017892628 @default.
- W2897874540 creator A5024927053 @default.
- W2897874540 creator A5039548485 @default.
- W2897874540 creator A5041447078 @default.
- W2897874540 creator A5058104480 @default.
- W2897874540 creator A5062541334 @default.
- W2897874540 creator A5090453486 @default.
- W2897874540 creator A5090849761 @default.
- W2897874540 date "2019-02-01" @default.
- W2897874540 modified "2023-10-14" @default.
- W2897874540 title "Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells" @default.
- W2897874540 cites W1499151513 @default.
- W2897874540 cites W1575585006 @default.
- W2897874540 cites W1674079630 @default.
- W2897874540 cites W1835190686 @default.
- W2897874540 cites W1964948851 @default.
- W2897874540 cites W1973647796 @default.
- W2897874540 cites W1977336621 @default.
- W2897874540 cites W1982361492 @default.
- W2897874540 cites W1983019708 @default.
- W2897874540 cites W1987735044 @default.
- W2897874540 cites W1992375755 @default.
- W2897874540 cites W1999337138 @default.
- W2897874540 cites W2002726823 @default.
- W2897874540 cites W2004417257 @default.
- W2897874540 cites W2006111867 @default.
- W2897874540 cites W2008501671 @default.
- W2897874540 cites W2013146483 @default.
- W2897874540 cites W2019918813 @default.
- W2897874540 cites W2025277638 @default.
- W2897874540 cites W2035536565 @default.
- W2897874540 cites W2041079472 @default.
- W2897874540 cites W2044549899 @default.
- W2897874540 cites W2049940924 @default.
- W2897874540 cites W2057999664 @default.
- W2897874540 cites W2063261544 @default.
- W2897874540 cites W2066094037 @default.
- W2897874540 cites W2076142854 @default.
- W2897874540 cites W2076379671 @default.
- W2897874540 cites W2078157388 @default.
- W2897874540 cites W2079003739 @default.
- W2897874540 cites W2081360252 @default.
- W2897874540 cites W2081593406 @default.
- W2897874540 cites W2088570448 @default.
- W2897874540 cites W2092722802 @default.
- W2897874540 cites W2097811455 @default.
- W2897874540 cites W2100519108 @default.
- W2897874540 cites W2102258628 @default.
- W2897874540 cites W2110471949 @default.
- W2897874540 cites W2111656053 @default.
- W2897874540 cites W2118514089 @default.
- W2897874540 cites W2130025456 @default.
- W2897874540 cites W2131799636 @default.
- W2897874540 cites W2131874142 @default.
- W2897874540 cites W2134053452 @default.
- W2897874540 cites W2143758098 @default.
- W2897874540 cites W2144490177 @default.
- W2897874540 cites W2146955123 @default.
- W2897874540 cites W2148911309 @default.
- W2897874540 cites W2150288590 @default.
- W2897874540 cites W2153111398 @default.
- W2897874540 cites W2153390615 @default.
- W2897874540 cites W2155394831 @default.
- W2897874540 cites W2168244648 @default.
- W2897874540 cites W2169859344 @default.
- W2897874540 cites W2272703292 @default.
- W2897874540 cites W2316651388 @default.
- W2897874540 cites W2331846333 @default.
- W2897874540 cites W2433064503 @default.
- W2897874540 cites W2463708289 @default.
- W2897874540 cites W2465055443 @default.
- W2897874540 cites W2507222891 @default.
- W2897874540 cites W2620547282 @default.
- W2897874540 cites W2749749452 @default.
- W2897874540 doi "https://doi.org/10.1016/j.jaut.2018.09.011" @default.
- W2897874540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318155" @default.
- W2897874540 hasPublicationYear "2019" @default.
- W2897874540 type Work @default.
- W2897874540 sameAs 2897874540 @default.
- W2897874540 citedByCount "28" @default.
- W2897874540 countsByYear W28978745402019 @default.
- W2897874540 countsByYear W28978745402020 @default.
- W2897874540 countsByYear W28978745402021 @default.
- W2897874540 countsByYear W28978745402022 @default.
- W2897874540 countsByYear W28978745402023 @default.
- W2897874540 crossrefType "journal-article" @default.
- W2897874540 hasAuthorship W2897874540A5005020998 @default.
- W2897874540 hasAuthorship W2897874540A5008158683 @default.
- W2897874540 hasAuthorship W2897874540A5012117525 @default.
- W2897874540 hasAuthorship W2897874540A5012467959 @default.
- W2897874540 hasAuthorship W2897874540A5017892628 @default.
- W2897874540 hasAuthorship W2897874540A5024927053 @default.