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- W2897879688 abstract "Dementia is one of the most common disease in South Korea. Active researches are underway for the early prediction of dementia, and image analysis is one of them. Among the structural changes in the brain caused by Alzheimer's disease, this study focused on cortical atrophy and changes related to ventricular enlargement, which are mainly observed at the early stage of onset. Finally We tried to explore that naphthol, one of the PHA(Polycyclic aromatic hydrocarbons), could be a factor in brain structural changes. A total of 769 subjects from a community-based cohort in South Korea were used in analysis. All subjects measured cortical thickness(mm), brain volume(m3), and ventricular volume(m3) for all areas of the brain by brain 3T MRI. To show a correlation between urinary naphthol level and structural change of the brain, the multiple linear regression method was used. The model was adjusted by age, sex, education level, body mass index, drinking, smoking, Physical activity, intracranial volume, family history of dementia, and other cardiovascular comorbidity. Subjects with neurological disorders, dementia and MCI(mild cognitive impairment) were excluded from the study. In multiple linear regression models, higher naphthol level showed a decline right entorhinal cortex- One of the biomarkers of early dementia prediction-(β=-0.0273, p-value : 0.0089), right superior parietal cortex(β=-0.0079, p-value : 0.0328), and left inferior parietal cortex(β=-0.0078, p-value : 0.0369). On the other hand, higher urinary naphthol level was associated with lateral ventricle(β=22.9236, p-value : 0.0248) and third ventricular(β=28.9807, p-value : 0.0325) size. The results of this analysis indicate that urinary naphthol level was partially related with brain cortex thinning and ventricular enlargement in subjects without neurological disease, or cognitive disorder." @default.
- W2897879688 created "2018-10-26" @default.
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- W2897879688 date "2018-07-01" @default.
- W2897879688 modified "2023-10-16" @default.
- W2897879688 title "P3‐569: THE ASSOCIATION OF URINARY NAPHTHOL LEVEL AND STRUCTURAL CHANGE OF THE BRAIN‐BRAIN CORTICAL THINNING AND VENTRICULAR ENLARGEMENT: A CROSS‐SECTIONAL STUDY" @default.
- W2897879688 doi "https://doi.org/10.1016/j.jalz.2018.06.1935" @default.
- W2897879688 hasPublicationYear "2018" @default.
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