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- W2897880757 abstract "Depressive symptoms in old age may reflect earliest stages of Alzheimer's disease (AD). In clinical routine, when depressive symptoms are present, it might be a challenge to differentiate between patients with cognitive impairment due to depression and those due to underlying AD. Through a retrospective analysis of data from outpatients of our memory clinic we aimed to identify neuropsychological tests that help to distinguish cognitive deficits due to and independent from AD in subjects with depressive symptoms. For outpatients of our memory clinic CERAD-NP was used as neuropsychological screening, depressive symptoms were assessed by the Geriatric Depression Scale (GDS). In cerebrospinal fluid (CSF) Aβ-1-42 and t-Tau was quantified. For this data analysis CSF-biomarkers were considered as in line with AD pathology when ratio of t-Tau/Aβ1-42 was ≥0.58. We calculated ROC curves and subsequently area under the curve (AUC) values and determined best neuropsychological tests to identify AD pathology in CSF. 379 subjects had no CSF abnormalities, 251 subjects showed CSF results in line with AD pathology. Of all examined neuropsychological tests, Word List Recall showed the highest AUC of 0.71 in subjects with GDS scores 0-10. In subjects with moderate and high GDS scores (11-20 and 21-30 respectively) Constructional Praxis Savings (CPS) revealed highest AUCs with 0.72 (moderate GDS scores) and 0.89 (high GDS scores). When continuously correlating AUC values of respective tests with GDS scores a general increase could be observed – the higher GDS scores, the higher AUC values." @default.
- W2897880757 created "2018-10-26" @default.
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- W2897880757 date "2018-07-01" @default.
- W2897880757 modified "2023-10-16" @default.
- W2897880757 title "P3‐212: CORRELATING NEUROPSYCHOLOGICAL TESTS WITH CEREBROSPINAL FLUID TO DISCRIMINATE AD FROM DEPRESSION" @default.
- W2897880757 doi "https://doi.org/10.1016/j.jalz.2018.06.1571" @default.
- W2897880757 hasPublicationYear "2018" @default.
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