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- W2897886305 abstract "En la actualidad existen diversas alternativas terapéuticas para modificar el curso de la esclerosis múltiple con un sólido sustento de guías de práctica y ensayos clínicos publicados; sin embargo, no existe un consenso unívoco en cuanto a los criterios de suspensión de la terapia, y son escasos los estudios abocados a este tema. Identificadas las razones para suspender la terapia modificadora de la enfermedad, esta revisión aborda este problema desde tres perspectivas: la plausibilidad biológica (edad, tiempo libre de actividad, evolución a formas progresivas, características de la medicación), la evidencia publicada (guías de práctica clínica, ensayos clínicos, estudios observacionales) y los valores y expectativas del paciente (participación en la toma de decisiones, postura del médico, costos para el sistema de salud). Se pretende, por lo tanto, identificar un perfil de paciente apto para la suspensión de la terapia mediante esta aproximación multidimensional. At present time, there are several therapeutic alternatives to modify the course of multiple sclerosis, with a solid support of published practice guidelines and clinical trials. However, there is no univocal consensus regarding the criteria for the discontinuation of therapy, and there are few studies referring to this topic. After identifying the reasons for discontinuing the disease-modifying therapy, this review addresses this issue from three different perspectives: biological plausibility (age, time free of activity, evolution to progressive forms, characteristics of the medication), published evidence (clinical practice guidelines, clinical trials, observational studies), and patient values and expectations (involvement in decision-making, doctor's position, costs for the health system). The aim, therefore, is to identify a patient profile suitable for the discontinuation of therapy through this multi-dimensional approach." @default.
- W2897886305 created "2018-10-26" @default.
- W2897886305 creator A5071850413 @default.
- W2897886305 date "2018-10-01" @default.
- W2897886305 modified "2023-10-18" @default.
- W2897886305 title "Suspensión de las terapias modificadoras de la enfermedad en esclerosis múltiple. Una aproximación multidimensional" @default.
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- W2897886305 doi "https://doi.org/10.1016/j.neuarg.2018.08.002" @default.
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