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- W2897889682 startingPage "159" @default.
- W2897889682 abstract "Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive system that regulates the transcription of multiple genes associated with growth, angiogenesis, proliferation, glucose transport, metabolism, pH regulation and cell death. However, aberrant HIF-1 activation contributes to the pathophysiology of several human diseases such as cancer, ischemic cardiovascular disorders, and pulmonary and kidney diseases. A growing body of evidence indicates that curcumin, a natural bioactive compound of turmeric root, significantly targets both HIF-1 subunits, but is more potent against HIF-1α. In this review, we have summarized the knowledge about the pharmacological effects of curcumin on HIF-1 and the related molecular mechanisms that may be effective candidates for the development of multi-targeted therapy for several human diseases." @default.
- W2897889682 created "2018-10-26" @default.
- W2897889682 creator A5005361897 @default.
- W2897889682 creator A5031560022 @default.
- W2897889682 creator A5032412684 @default.
- W2897889682 creator A5074208520 @default.
- W2897889682 date "2018-11-01" @default.
- W2897889682 modified "2023-10-14" @default.
- W2897889682 title "Effects of curcumin on hypoxia-inducible factor as a new therapeutic target" @default.
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