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• W2897890553 abstract "High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site." @default.
• W2897890553 created "2018-10-26" @default.
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• W2897890553 date "2018-10-19" @default.
• W2897890553 modified "2023-10-17" @default.
• W2897890553 title "Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway" @default.
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• W2897890553 doi "https://doi.org/10.7554/elife.40444" @default.
• W2897890553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6231770" @default.
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