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- W2897897494 abstract "Abstract Aim Bone-seeking radiopharmaceuticals are potential therapeutic tools for bone marrow ablation in patients with multiple myeloma. In this procedure, estimation of radiation absorbed dose received by the target and non-target organs is one of the most important parameters that should be undertaken. This research revolves around the absorbed dose to human organs after 90 Y-BPAMD injection. Materials and methods 90 Y-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid ( 90 Y-BPAMD) complex was successfully prepared under optimised conditions. The human absorbed dose of the complex was estimated based on the biodistribution data on rats using the radiation-absorbed dose-assessment resource method. The target to non-target absorbed dose ratios for the complex was compared with the ratios for 166 Ho-DOTMP, as the main radiopharmaceutical for bone marrow ablation. Results As expected, the highest amounts of absorbed dose were observed in the bone surface and the bone marrow with 2·52 and 2·29 mGy/MBq, respectively. The red marrow to the most organ absorbed dose ratios for 90 Y-BPAMD are much higher than the ratios for 166 Ho-DOTMP. Findings 90 Y-BPAMD has interesting characteristics compared with 166 Ho-DOTMP and can be considered as a high potential agent for bone marrow ablative therapy of the patient with multiple myeloma." @default.
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- W2897897494 date "2018-10-23" @default.
- W2897897494 modified "2023-09-24" @default.
- W2897897494 title "Preliminary dosimetric evaluation of 90Y-BPAMD as a potential agent for bone marrow ablative therapy" @default.
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- W2897897494 doi "https://doi.org/10.1017/s146039691800047x" @default.
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