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- W2897900263 abstract "Summary Centriole is an essential structure with multiple functions in cellular processes. Centriole biogenesis and homeostasis is tightly regulated. Using electron cryo-tomography (cryoET) we present the structure of procentrioles from Chlamydomonas reinhardtii . We identified a set of non-tubulin components attached to the triplet microtubule (MT), many are at the junctions of tubules likely to reinforce the triplet. We describe structure of the A-C linker that bridges neighboring triplets. We find that POC1 is an integral component of the A-C linker. Its conserved WD40 β-propeller domain provides sites for attachment to other A-C linker components. The twist of A-C linker results in an iris diaphragm-like motion of the triplets in the longitudinal direction of procentriole. Finally, we identified two assembly intermediates at the growing ends of procentriole allowing us to propose a model for the procentriole assembly. Our results provide a comprehensive structural framework for understanding the molecular mechanisms underpinning procentriole biogenesis and assembly." @default.
- W2897900263 created "2018-10-26" @default.
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- W2897900263 date "2018-10-12" @default.
- W2897900263 modified "2023-09-27" @default.
- W2897900263 title "Electron Cryo-Tomography Provides Insight into Procentriole Architecture and Assembly Mechanism" @default.
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- W2897900263 doi "https://doi.org/10.1101/442590" @default.
- W2897900263 hasPublicationYear "2018" @default.
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