Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897901903> ?p ?o ?g. }
- W2897901903 endingPage "564" @default.
- W2897901903 startingPage "564" @default.
- W2897901903 abstract "The Saccharomycetaceae yeast family recently became recognized for expanding of the repertoire of different dsRNA-based viruses, highlighting the need for understanding of their cross-dependence. We isolated the Saccharomyces paradoxus AML-15-66 killer strain from spontaneous fermentation of serviceberries and identified helper and satellite viruses of the family Totiviridae, which are responsible for the killing phenotype. The corresponding full dsRNA genomes of viruses have been cloned and sequenced. Sequence analysis of SpV-LA-66 identified it to be most similar to S. paradoxus LA-28 type viruses, while SpV-M66 was mostly similar to the SpV-M21 virus. Sequence and functional analysis revealed significant differences between the K66 and the K28 toxins. The structural organization of the K66 protein resembled those of the K1/K2 type toxins. The AML-15-66 strain possesses the most expressed killing property towards the K28 toxin-producing strain. A genetic screen performed on S. cerevisiae YKO library strains revealed 125 gene products important for the functioning of the S. paradoxus K66 toxin, with 85% of the discovered modulators shared with S. cerevisiae K2 or K1 toxins. Investigation of the K66 protein binding to cells and different polysaccharides implies the β-1,6 glucans to be the primary receptors of S. paradoxus K66 toxin. For the first time, we demonstrated the coherent habitation of different types of helper and satellite viruses in a wild-type S. paradoxus strain." @default.
- W2897901903 created "2018-10-26" @default.
- W2897901903 creator A5018684408 @default.
- W2897901903 creator A5021455022 @default.
- W2897901903 creator A5023964755 @default.
- W2897901903 creator A5030200606 @default.
- W2897901903 creator A5036350659 @default.
- W2897901903 creator A5039559811 @default.
- W2897901903 creator A5048057401 @default.
- W2897901903 creator A5062076276 @default.
- W2897901903 date "2018-10-16" @default.
- W2897901903 modified "2023-10-16" @default.
- W2897901903 title "Saccharomyces paradoxus K66 Killer System Evidences Expanded Assortment of Helper and Satellite Viruses" @default.
- W2897901903 cites W1517428866 @default.
- W2897901903 cites W1527146660 @default.
- W2897901903 cites W1550334320 @default.
- W2897901903 cites W1563817153 @default.
- W2897901903 cites W1821970762 @default.
- W2897901903 cites W1905257993 @default.
- W2897901903 cites W1921423587 @default.
- W2897901903 cites W1928277783 @default.
- W2897901903 cites W1962675269 @default.
- W2897901903 cites W1968716686 @default.
- W2897901903 cites W1985450725 @default.
- W2897901903 cites W1986678390 @default.
- W2897901903 cites W2001358232 @default.
- W2897901903 cites W2005242762 @default.
- W2897901903 cites W2005424092 @default.
- W2897901903 cites W2007956260 @default.
- W2897901903 cites W2009351539 @default.
- W2897901903 cites W2010499900 @default.
- W2897901903 cites W2012900889 @default.
- W2897901903 cites W2015021263 @default.
- W2897901903 cites W2018324060 @default.
- W2897901903 cites W2019652308 @default.
- W2897901903 cites W2028682583 @default.
- W2897901903 cites W2033569116 @default.
- W2897901903 cites W2036280947 @default.
- W2897901903 cites W2050665726 @default.
- W2897901903 cites W2057545775 @default.
- W2897901903 cites W2072708496 @default.
- W2897901903 cites W2073031950 @default.
- W2897901903 cites W2095253009 @default.
- W2897901903 cites W2095765187 @default.
- W2897901903 cites W2096510358 @default.
- W2897901903 cites W2098553908 @default.
- W2897901903 cites W2106019576 @default.
- W2897901903 cites W2111647009 @default.
- W2897901903 cites W2112623352 @default.
- W2897901903 cites W2116641370 @default.
- W2897901903 cites W2124088653 @default.
- W2897901903 cites W2124809056 @default.
- W2897901903 cites W2133294061 @default.
- W2897901903 cites W2146019635 @default.
- W2897901903 cites W2148055079 @default.
- W2897901903 cites W2153803181 @default.
- W2897901903 cites W2159694586 @default.
- W2897901903 cites W2166232730 @default.
- W2897901903 cites W2170392103 @default.
- W2897901903 cites W2171030481 @default.
- W2897901903 cites W2172189885 @default.
- W2897901903 cites W2195089071 @default.
- W2897901903 cites W2224056471 @default.
- W2897901903 cites W2305099691 @default.
- W2897901903 cites W2317087819 @default.
- W2897901903 cites W2400852125 @default.
- W2897901903 cites W2416758791 @default.
- W2897901903 cites W2419206018 @default.
- W2897901903 cites W2423689767 @default.
- W2897901903 cites W2560799757 @default.
- W2897901903 cites W2738440632 @default.
- W2897901903 cites W2755034139 @default.
- W2897901903 cites W2756134729 @default.
- W2897901903 cites W2764154339 @default.
- W2897901903 cites W2765855663 @default.
- W2897901903 cites W2778213285 @default.
- W2897901903 cites W2949224746 @default.
- W2897901903 cites W311549123 @default.
- W2897901903 cites W4253152942 @default.
- W2897901903 cites W569784 @default.
- W2897901903 doi "https://doi.org/10.3390/v10100564" @default.
- W2897901903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213463" @default.
- W2897901903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30332789" @default.
- W2897901903 hasPublicationYear "2018" @default.
- W2897901903 type Work @default.
- W2897901903 sameAs 2897901903 @default.
- W2897901903 citedByCount "19" @default.
- W2897901903 countsByYear W28979019032019 @default.
- W2897901903 countsByYear W28979019032020 @default.
- W2897901903 countsByYear W28979019032021 @default.
- W2897901903 countsByYear W28979019032022 @default.
- W2897901903 countsByYear W28979019032023 @default.
- W2897901903 crossrefType "journal-article" @default.
- W2897901903 hasAuthorship W2897901903A5018684408 @default.
- W2897901903 hasAuthorship W2897901903A5021455022 @default.
- W2897901903 hasAuthorship W2897901903A5023964755 @default.
- W2897901903 hasAuthorship W2897901903A5030200606 @default.
- W2897901903 hasAuthorship W2897901903A5036350659 @default.