FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897907274> ?p ?o ?g. }

• W2897907274 endingPage "575" @default.
• W2897907274 startingPage "564" @default.
• W2897907274 abstract "Classic Hodgkin lymphoma tumor cells express a functional CCR5 receptor, and tumor tissues express high CCL5 levels, suggesting that CCL5-CCR5 signaling is involved in tumor-microenvironment formation and tumor growth. Using the CCR5 antagonist, maraviroc, and a neutralizing anti-CCL5 antibody, we found that CCL5 secreted by classic Hodgkin lymphoma cells recruited mesenchymal stromal cells and monocytes. The education of mesenchymal stromal cells by tumor cell-conditioned medium enhanced mesenchymal stromal cells' proliferation and CCL5 secretion. In turn, educated mesenchymal stromal cell-conditioned medium increased the clonogenic growth of tumor cells and monocyte migration, but these effects were reduced by maraviroc. Monocyte education by tumor cell-conditioned medium induced their growth and reprogrammed them towards immunosuppressive tumor-associated macrophages that expressed IDO and PD-L1 and secreted IL-10, CCL17 and TGF-β. Educated monocyte-conditioned medium slowed the growth of phytohemagglutinin-activated lymphocytes. Maraviroc decreased tumor cell growth and synergized with doxorubicin and brentuximab vedotin. A three-dimensional heterospheroid assay showed that maraviroc counteracted both the formation and viability of heterospheroids generated by co-cultivation of tumor cells with mesenchymal stromal cells and monocytes. In mice bearing tumor cell xenografts, maraviroc reduced tumor growth by more than 50% and inhibited monocyte accumulation, without weight loss. Finally, in classic Hodgkin lymphoma human tumor tissues, CCL5 and CD68 expression correlated positively, and patients with high CCL5 levels had poor prognosis. In conclusion, since the present challenges are to find molecules counteracting the formation of the immunosuppressive tumor microenvironment or new, less toxic drug combinations, the repurposed drug maraviroc may represent a new opportunity for classic Hodgkin lym phoma treatment." @default.
• W2897907274 created "2018-10-26" @default.
• W2897907274 creator A5006278471 @default.
• W2897907274 creator A5008340388 @default.
• W2897907274 creator A5016581593 @default.
• W2897907274 creator A5020517759 @default.
• W2897907274 creator A5032799786 @default.
• W2897907274 creator A5079213910 @default.
• W2897907274 date "2018-10-11" @default.
• W2897907274 modified "2023-10-14" @default.
• W2897907274 title "CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth" @default.
• W2897907274 cites W1520623778 @default.
• W2897907274 cites W1539775800 @default.
• W2897907274 cites W1596519391 @default.
• W2897907274 cites W1982673084 @default.
• W2897907274 cites W1983592978 @default.
• W2897907274 cites W1984778449 @default.
• W2897907274 cites W1996436013 @default.
• W2897907274 cites W2002127959 @default.
• W2897907274 cites W2011770999 @default.
• W2897907274 cites W2013229326 @default.
• W2897907274 cites W2040016252 @default.
• W2897907274 cites W2047209914 @default.
• W2897907274 cites W2056267869 @default.
• W2897907274 cites W2058174884 @default.
• W2897907274 cites W2068693591 @default.
• W2897907274 cites W2071189905 @default.
• W2897907274 cites W2074047902 @default.
• W2897907274 cites W2074727737 @default.
• W2897907274 cites W2102054577 @default.
• W2897907274 cites W2116455112 @default.
• W2897907274 cites W2131285836 @default.
• W2897907274 cites W2148926267 @default.
• W2897907274 cites W2176045535 @default.
• W2897907274 cites W2178298575 @default.
• W2897907274 cites W2331667420 @default.
• W2897907274 cites W2336656900 @default.
• W2897907274 cites W2345367149 @default.
• W2897907274 cites W2349176297 @default.
• W2897907274 cites W2356117256 @default.
• W2897907274 cites W2381078255 @default.
• W2897907274 cites W2403976714 @default.
• W2897907274 cites W2463998611 @default.
• W2897907274 cites W2509240907 @default.
• W2897907274 cites W2515199119 @default.
• W2897907274 cites W2523964815 @default.
• W2897907274 cites W2582686270 @default.
• W2897907274 cites W2606222190 @default.
• W2897907274 cites W2620723923 @default.
• W2897907274 cites W2753945613 @default.
• W2897907274 cites W2766776368 @default.
• W2897907274 cites W2805358123 @default.
• W2897907274 cites W2883090557 @default.
• W2897907274 doi "https://doi.org/10.3324/haematol.2018.196725" @default.
• W2897907274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6395337" @default.
• W2897907274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30309853" @default.
• W2897907274 hasPublicationYear "2018" @default.
• W2897907274 type Work @default.
• W2897907274 sameAs 2897907274 @default.
• W2897907274 citedByCount "57" @default.
• W2897907274 countsByYear W28979072742019 @default.
• W2897907274 countsByYear W28979072742020 @default.
• W2897907274 countsByYear W28979072742021 @default.
• W2897907274 countsByYear W28979072742022 @default.
• W2897907274 countsByYear W28979072742023 @default.
• W2897907274 crossrefType "journal-article" @default.
• W2897907274 hasAuthorship W2897907274A5006278471 @default.
• W2897907274 hasAuthorship W2897907274A5008340388 @default.
• W2897907274 hasAuthorship W2897907274A5016581593 @default.
• W2897907274 hasAuthorship W2897907274A5020517759 @default.
• W2897907274 hasAuthorship W2897907274A5032799786 @default.
• W2897907274 hasAuthorship W2897907274A5079213910 @default.
• W2897907274 hasBestOaLocation W28979072741 @default.
• W2897907274 hasConcept C116484652 @default.
• W2897907274 hasConcept C12823836 @default.
• W2897907274 hasConcept C13373296 @default.
• W2897907274 hasConcept C16930146 @default.
• W2897907274 hasConcept C185592680 @default.
• W2897907274 hasConcept C198826908 @default.
• W2897907274 hasConcept C203014093 @default.
• W2897907274 hasConcept C2776090121 @default.
• W2897907274 hasConcept C2776107976 @default.
• W2897907274 hasConcept C2776914184 @default.
• W2897907274 hasConcept C2778899366 @default.
• W2897907274 hasConcept C2781184567 @default.
• W2897907274 hasConcept C3013748606 @default.
• W2897907274 hasConcept C3020616263 @default.
• W2897907274 hasConcept C37044404 @default.
• W2897907274 hasConcept C502942594 @default.
• W2897907274 hasConcept C79484868 @default.
• W2897907274 hasConcept C86803240 @default.
• W2897907274 hasConcept C8891405 @default.
• W2897907274 hasConcept C95444343 @default.
• W2897907274 hasConceptScore W2897907274C116484652 @default.
• W2897907274 hasConceptScore W2897907274C12823836 @default.
• W2897907274 hasConceptScore W2897907274C13373296 @default.
• W2897907274 hasConceptScore W2897907274C16930146 @default.
• W2897907274 hasConceptScore W2897907274C185592680 @default.

• next