FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897907631> ?p ?o ?g. }

• W2897907631 abstract "Many factors influence human facial morphology, including genetics, age, nutrition, biomechanical forces, and endocrine factors. Moreover, facial features clearly differ between males and females, and these differences are driven primarily by the influence of sex hormones during growth and development. Specific genetic variants are known to influence circulating sex hormone levels in humans, which we hypothesize, in turn, affect facial features. In this study, we investigated the effects of testosterone-related genetic variants on facial morphology. We tested 32 genetic variants across 22 candidate genes related to levels of testosterone, sex hormone-binding globulin (SHGB) and dehydroepiandrosterone sulfate (DHEAS) in three cohorts of healthy individuals for which 3D facial surface images were available (Pittsburgh 3DFN, Penn State and ALSPAC cohorts; total n=7418). Facial shape was described using a recently developed extension of the dense-surface correspondence approach, in which the 3D facial surface was partitioned into a set of 63 hierarchically organized modules. Each variant was tested against each of the facial surface modules in a multivariate genetic association-testing framework and meta-analyzed. Additionally, the association between these candidate SNPs and five facial ratios was investigated in the Pittsburgh 3DFN cohort. Two significant associations involving intronic variants of SHBG were found: both rs12150660 (p=1.07E-07) and rs1799941 (p=6.15E-06) showed an effect on mandible shape. Rs8023580 (an intronic variant of NR2F2-AS1) showed an association with the total and upper facial width to height ratios (p=9.61E-04 and p=7.35E-04 respectively). These results indicate that testosterone-related genetic variants affect normal-range facial morphology, and in particular, facial features known to exhibit strong sexual dimorphism in humans." @default.
• W2897907631 created "2018-10-26" @default.
• W2897907631 creator A5002662919 @default.
• W2897907631 creator A5012408598 @default.
• W2897907631 creator A5020534674 @default.
• W2897907631 creator A5023309695 @default.
• W2897907631 creator A5029369497 @default.
• W2897907631 creator A5030596121 @default.
• W2897907631 creator A5033510739 @default.
• W2897907631 creator A5044173188 @default.
• W2897907631 creator A5044370575 @default.
• W2897907631 creator A5044858589 @default.
• W2897907631 creator A5052349035 @default.
• W2897907631 creator A5054286392 @default.
• W2897907631 creator A5063523220 @default.
• W2897907631 creator A5064886913 @default.
• W2897907631 creator A5066801964 @default.
• W2897907631 creator A5072385531 @default.
• W2897907631 creator A5089457280 @default.
• W2897907631 date "2018-10-23" @default.
• W2897907631 modified "2023-09-26" @default.
• W2897907631 title "SNPs Associated With Testosterone Levels Influence Human Facial Morphology" @default.
• W2897907631 cites W1543017846 @default.
• W2897907631 cites W1919291954 @default.
• W2897907631 cites W1967841080 @default.
• W2897907631 cites W1968703681 @default.
• W2897907631 cites W1980887908 @default.
• W2897907631 cites W1992436001 @default.
• W2897907631 cites W1996642718 @default.
• W2897907631 cites W2016169429 @default.
• W2897907631 cites W2026884584 @default.
• W2897907631 cites W2058852373 @default.
• W2897907631 cites W2076095071 @default.
• W2897907631 cites W2081518759 @default.
• W2897907631 cites W2089523057 @default.
• W2897907631 cites W2096791516 @default.
• W2897907631 cites W2107755054 @default.
• W2897907631 cites W2108434880 @default.
• W2897907631 cites W2111241216 @default.
• W2897907631 cites W2113690607 @default.
• W2897907631 cites W2114964088 @default.
• W2897907631 cites W2115307144 @default.
• W2897907631 cites W2116643194 @default.
• W2897907631 cites W2118685149 @default.
• W2897907631 cites W2118890802 @default.
• W2897907631 cites W2119444539 @default.
• W2897907631 cites W2122481149 @default.
• W2897907631 cites W2123263006 @default.
• W2897907631 cites W2131183102 @default.
• W2897907631 cites W2134471459 @default.
• W2897907631 cites W2135751677 @default.
• W2897907631 cites W2137396992 @default.
• W2897907631 cites W2139893960 @default.
• W2897907631 cites W2143509157 @default.
• W2897907631 cites W2147330000 @default.
• W2897907631 cites W2150715414 @default.
• W2897907631 cites W2152828142 @default.
• W2897907631 cites W2156159982 @default.
• W2897907631 cites W2159774735 @default.
• W2897907631 cites W2160643014 @default.
• W2897907631 cites W2161633633 @default.
• W2897907631 cites W2165860473 @default.
• W2897907631 cites W2170384145 @default.
• W2897907631 cites W2171390838 @default.
• W2897907631 cites W2267401333 @default.
• W2897907631 cites W2338293654 @default.
• W2897907631 cites W2340514036 @default.
• W2897907631 cites W2401282820 @default.
• W2897907631 cites W2475331565 @default.
• W2897907631 cites W2518076847 @default.
• W2897907631 cites W2783771370 @default.
• W2897907631 cites W2789017128 @default.
• W2897907631 cites W2806414211 @default.
• W2897907631 cites W29779864 @default.
• W2897907631 cites W883188793 @default.
• W2897907631 doi "https://doi.org/10.3389/fgene.2018.00497" @default.
• W2897907631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6206510" @default.
• W2897907631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405702" @default.
• W2897907631 hasPublicationYear "2018" @default.
• W2897907631 type Work @default.
• W2897907631 sameAs 2897907631 @default.
• W2897907631 citedByCount "22" @default.
• W2897907631 countsByYear W28979076312019 @default.
• W2897907631 countsByYear W28979076312020 @default.
• W2897907631 countsByYear W28979076312021 @default.
• W2897907631 countsByYear W28979076312022 @default.
• W2897907631 countsByYear W28979076312023 @default.
• W2897907631 crossrefType "journal-article" @default.
• W2897907631 hasAuthorship W2897907631A5002662919 @default.
• W2897907631 hasAuthorship W2897907631A5012408598 @default.
• W2897907631 hasAuthorship W2897907631A5020534674 @default.
• W2897907631 hasAuthorship W2897907631A5023309695 @default.
• W2897907631 hasAuthorship W2897907631A5029369497 @default.
• W2897907631 hasAuthorship W2897907631A5030596121 @default.
• W2897907631 hasAuthorship W2897907631A5033510739 @default.
• W2897907631 hasAuthorship W2897907631A5044173188 @default.
• W2897907631 hasAuthorship W2897907631A5044370575 @default.
• W2897907631 hasAuthorship W2897907631A5044858589 @default.
• W2897907631 hasAuthorship W2897907631A5052349035 @default.
• W2897907631 hasAuthorship W2897907631A5054286392 @default.

• next