Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897913196> ?p ?o ?g. }
- W2897913196 abstract "Cellular immunotherapy with autologous or allogeneic T cells, genetically engineered to express chimeric antigen receptors (CARs) or T-cell receptors, in order to redirect their cytotoxic specificity toward malignant cells, is emerging as a promising new treatment modality. The most advanced approach in clinical development is the use of anti-CD19 CAR T-cells for the treatment of CD19+ B-cell malignancies, including acute lymphocytic leukemia (ALL). Areas covered: Recently, the Food and Drug Administration (FDA) approved the first anti-CD19 CAR T-cell product, tisagenlecleucel, for the treatment of pediatric and young adult patients with relapsed/refractory ALL. In this overview, we described the advances in the field, including a summary of clinical trials with tisagenlecleucel in ALL published to date. Expert opinion: CAR T-cell therapy has been developed in the context of small clinical studies and very few centers have had to deal with the challenges of managing CAR T-cells administration. However, this approach is likely to become a standard option for patients with relapsed/refractory B-cell lineage ALL." @default.
- W2897913196 created "2018-10-26" @default.
- W2897913196 creator A5067916177 @default.
- W2897913196 creator A5078817313 @default.
- W2897913196 date "2018-10-12" @default.
- W2897913196 modified "2023-09-30" @default.
- W2897913196 title "Tisagenlecleucel-T for the treatment of acute lymphocytic leukemia" @default.
- W2897913196 cites W1604141497 @default.
- W2897913196 cites W1619537825 @default.
- W2897913196 cites W1767113662 @default.
- W2897913196 cites W1839053269 @default.
- W2897913196 cites W1879221139 @default.
- W2897913196 cites W1881216623 @default.
- W2897913196 cites W1967517831 @default.
- W2897913196 cites W1969989455 @default.
- W2897913196 cites W1977380325 @default.
- W2897913196 cites W1985579610 @default.
- W2897913196 cites W1987446594 @default.
- W2897913196 cites W1988623079 @default.
- W2897913196 cites W1999573477 @default.
- W2897913196 cites W2002132740 @default.
- W2897913196 cites W2003624697 @default.
- W2897913196 cites W2010607826 @default.
- W2897913196 cites W2012687212 @default.
- W2897913196 cites W2023761225 @default.
- W2897913196 cites W2047205338 @default.
- W2897913196 cites W2051549641 @default.
- W2897913196 cites W2055482234 @default.
- W2897913196 cites W2057389857 @default.
- W2897913196 cites W2064272625 @default.
- W2897913196 cites W2068302119 @default.
- W2897913196 cites W2068646465 @default.
- W2897913196 cites W2069637569 @default.
- W2897913196 cites W2072434377 @default.
- W2897913196 cites W2076560655 @default.
- W2897913196 cites W2082708772 @default.
- W2897913196 cites W2086450075 @default.
- W2897913196 cites W2089445567 @default.
- W2897913196 cites W2090340916 @default.
- W2897913196 cites W2099570622 @default.
- W2897913196 cites W2105400883 @default.
- W2897913196 cites W2112359076 @default.
- W2897913196 cites W2118796952 @default.
- W2897913196 cites W2129702476 @default.
- W2897913196 cites W2130338247 @default.
- W2897913196 cites W2134118606 @default.
- W2897913196 cites W2141019574 @default.
- W2897913196 cites W2141539055 @default.
- W2897913196 cites W2149699468 @default.
- W2897913196 cites W2154534003 @default.
- W2897913196 cites W2168091280 @default.
- W2897913196 cites W2219506342 @default.
- W2897913196 cites W2258336271 @default.
- W2897913196 cites W2265134611 @default.
- W2897913196 cites W2283468082 @default.
- W2897913196 cites W2325322965 @default.
- W2897913196 cites W2340435799 @default.
- W2897913196 cites W2342423058 @default.
- W2897913196 cites W2408097265 @default.
- W2897913196 cites W2413807845 @default.
- W2897913196 cites W2417246715 @default.
- W2897913196 cites W2461122889 @default.
- W2897913196 cites W2500019491 @default.
- W2897913196 cites W2500107307 @default.
- W2897913196 cites W2513573571 @default.
- W2897913196 cites W2516611622 @default.
- W2897913196 cites W2525034031 @default.
- W2897913196 cites W2530965063 @default.
- W2897913196 cites W2557037793 @default.
- W2897913196 cites W2560389151 @default.
- W2897913196 cites W2566677727 @default.
- W2897913196 cites W2567117613 @default.
- W2897913196 cites W2567664749 @default.
- W2897913196 cites W2583070206 @default.
- W2897913196 cites W2588227241 @default.
- W2897913196 cites W2590406062 @default.
- W2897913196 cites W2591709377 @default.
- W2897913196 cites W2592081641 @default.
- W2897913196 cites W2595083348 @default.
- W2897913196 cites W2595846412 @default.
- W2897913196 cites W2596309953 @default.
- W2897913196 cites W2596837612 @default.
- W2897913196 cites W2603921376 @default.
- W2897913196 cites W2605782354 @default.
- W2897913196 cites W2606470712 @default.
- W2897913196 cites W2608184170 @default.
- W2897913196 cites W2618582732 @default.
- W2897913196 cites W2653911491 @default.
- W2897913196 cites W2693970509 @default.
- W2897913196 cites W2728861520 @default.
- W2897913196 cites W2735691291 @default.
- W2897913196 cites W2739211009 @default.
- W2897913196 cites W2739972212 @default.
- W2897913196 cites W2754562068 @default.
- W2897913196 cites W2762392941 @default.
- W2897913196 cites W2787301955 @default.
- W2897913196 cites W2794874600 @default.
- W2897913196 cites W2891289348 @default.
- W2897913196 cites W2891931112 @default.
- W2897913196 cites W2979678869 @default.