Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897916102> ?p ?o ?g. }
- W2897916102 endingPage "31" @default.
- W2897916102 startingPage "24" @default.
- W2897916102 abstract "Organophosphates (OPs) are a class of chemicals commonly used in agriculture as pesticides, that can often lead to severe toxicity in humans. Paraoxonase-1 (PON1) belongs to a family of A-esterases and hydrolyses several OPs while also serving other biological roles. Two main genetic polymorphisms have been shown to affect enzymatic ability; an A > G transition in the 192nd position (192 Q/R, rs662), and an A > T at codon 55 (55 M/L, rs854560). In this review, we searched PubMed for relevant articles published from its inception till June 2018 and included publications from 1996 to 2018. We aimed to address the distribution of the polymorphisms in various populations, the way they affect enzymatic activity and the possible use of PON1 as a biomarker. The polymorphisms present great heterogeneity between populations, with the data being clearer over 192 Q/R, and this heterogeneity is related to the phylogenetic origins of each population. Concerning enzymatic activity, the different genotypes react better or worse to different OP substrates, with studies presenting a variety of findings. Detecting the “paraoxonase status” of an individual -referring to PON1 function- seems to be important in predicting OP toxicity, as studies have shown that some specific-genotype individuals present symptoms of toxicity in higher rates than others. We are strongly convinced that in order for the scientific community to reach a consensus over which polymorphisms confer susceptibility to toxicity and whether PON1 can eventually be used as a biomarker, more studies need to be carried out, since the data thus far does not seem to reach a universal conclusion." @default.
- W2897916102 created "2018-10-26" @default.
- W2897916102 creator A5004326313 @default.
- W2897916102 creator A5007185732 @default.
- W2897916102 creator A5020623639 @default.
- W2897916102 creator A5032663940 @default.
- W2897916102 creator A5035503566 @default.
- W2897916102 creator A5062847930 @default.
- W2897916102 creator A5070098215 @default.
- W2897916102 creator A5073434880 @default.
- W2897916102 creator A5074077365 @default.
- W2897916102 creator A5074264303 @default.
- W2897916102 date "2019-01-01" @default.
- W2897916102 modified "2023-10-16" @default.
- W2897916102 title "Paraoxonase-1 genetic polymorphisms in organophosphate metabolism" @default.
- W2897916102 cites W1221412131 @default.
- W2897916102 cites W1834765498 @default.
- W2897916102 cites W1869060308 @default.
- W2897916102 cites W1964410653 @default.
- W2897916102 cites W1966830656 @default.
- W2897916102 cites W1969440499 @default.
- W2897916102 cites W1969442348 @default.
- W2897916102 cites W1974150631 @default.
- W2897916102 cites W1975732178 @default.
- W2897916102 cites W1976658143 @default.
- W2897916102 cites W1977109232 @default.
- W2897916102 cites W1979302736 @default.
- W2897916102 cites W1979956933 @default.
- W2897916102 cites W1984092083 @default.
- W2897916102 cites W1987072296 @default.
- W2897916102 cites W1988491355 @default.
- W2897916102 cites W1989963651 @default.
- W2897916102 cites W1995314634 @default.
- W2897916102 cites W1997004368 @default.
- W2897916102 cites W2001001815 @default.
- W2897916102 cites W2007306216 @default.
- W2897916102 cites W2007737493 @default.
- W2897916102 cites W2009059138 @default.
- W2897916102 cites W2011726738 @default.
- W2897916102 cites W2014874996 @default.
- W2897916102 cites W2016151026 @default.
- W2897916102 cites W2017181323 @default.
- W2897916102 cites W2031452828 @default.
- W2897916102 cites W2033661020 @default.
- W2897916102 cites W2040351113 @default.
- W2897916102 cites W2041383091 @default.
- W2897916102 cites W2044586141 @default.
- W2897916102 cites W2044659011 @default.
- W2897916102 cites W2045124367 @default.
- W2897916102 cites W2046250638 @default.
- W2897916102 cites W2049533570 @default.
- W2897916102 cites W2054888149 @default.
- W2897916102 cites W2055424584 @default.
- W2897916102 cites W2066070014 @default.
- W2897916102 cites W2067815170 @default.
- W2897916102 cites W2068256402 @default.
- W2897916102 cites W2071230027 @default.
- W2897916102 cites W2073499417 @default.
- W2897916102 cites W2074532601 @default.
- W2897916102 cites W2074798171 @default.
- W2897916102 cites W2076854142 @default.
- W2897916102 cites W2078503590 @default.
- W2897916102 cites W2085697999 @default.
- W2897916102 cites W2086101157 @default.
- W2897916102 cites W2095683077 @default.
- W2897916102 cites W2099040294 @default.
- W2897916102 cites W2099720133 @default.
- W2897916102 cites W2100671310 @default.
- W2897916102 cites W2101154649 @default.
- W2897916102 cites W2105031306 @default.
- W2897916102 cites W2105463986 @default.
- W2897916102 cites W2108039242 @default.
- W2897916102 cites W2128794916 @default.
- W2897916102 cites W2140059081 @default.
- W2897916102 cites W2143167699 @default.
- W2897916102 cites W2144618593 @default.
- W2897916102 cites W2152407826 @default.
- W2897916102 cites W2164259487 @default.
- W2897916102 cites W2171544228 @default.
- W2897916102 cites W2171911597 @default.
- W2897916102 cites W2210299797 @default.
- W2897916102 cites W2320147751 @default.
- W2897916102 cites W2337186319 @default.
- W2897916102 cites W2405907603 @default.
- W2897916102 cites W2510403783 @default.
- W2897916102 cites W2583709076 @default.
- W2897916102 cites W2774317384 @default.
- W2897916102 cites W2789720481 @default.
- W2897916102 cites W2801745996 @default.
- W2897916102 cites W2803206700 @default.
- W2897916102 cites W2806069880 @default.
- W2897916102 cites W2883910348 @default.
- W2897916102 cites W2884221862 @default.
- W2897916102 cites W32351145 @default.
- W2897916102 doi "https://doi.org/10.1016/j.tox.2018.10.012" @default.
- W2897916102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359673" @default.
- W2897916102 hasPublicationYear "2019" @default.
- W2897916102 type Work @default.