FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897917666> ?p ?o ?g. }

• W2897917666 abstract "Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This chronic liver disease has a poorly understood etiology and demonstrates sexual dimorphisms. We aim to examine the molecular mechanisms underlying sexual dimorphisms in NAFLD pathogenesis through a comprehensive multi-omics study. We integrated genomics (DNA variations), transcriptomics of liver and adipose tissue, and phenotypic data of NAFLD derived from female mice of ~ 100 strains included in the hybrid mouse diversity panel (HMDP) and compared the NAFLD molecular pathways and gene networks between sexes.We identified both shared and sex-specific biological processes for NAFLD. Adaptive immunity, branched chain amino acid metabolism, oxidative phosphorylation, and cell cycle/apoptosis were shared between sexes. Among the sex-specific pathways were vitamins and cofactors metabolism and ion channel transport for females, and phospholipid, lysophospholipid, and phosphatidylinositol metabolism and insulin signaling for males. Additionally, numerous lipid and insulin-related pathways and inflammatory processes in the adipose and liver tissue appeared to show more prominent association with NAFLD in male HMDP. Using data-driven network modeling, we identified plausible sex-specific and tissue-specific regulatory genes as well as those that are shared between sexes. These key regulators orchestrate the NAFLD pathways in a sex- and tissue-specific manner. Gonadectomy experiments support that sex hormones may partially underlie the sexually dimorphic genes and pathways involved in NAFLD.Our multi-omics integrative study reveals sex- and tissue-specific genes, processes, and networks underlying sexual dimorphism in NAFLD and may facilitate sex-specific precision medicine." @default.
• W2897917666 created "2018-10-26" @default.
• W2897917666 creator A5000117288 @default.
• W2897917666 creator A5016721130 @default.
• W2897917666 creator A5017019764 @default.
• W2897917666 creator A5020562578 @default.
• W2897917666 creator A5024672193 @default.
• W2897917666 creator A5024741961 @default.
• W2897917666 creator A5030143970 @default.
• W2897917666 creator A5061865071 @default.
• W2897917666 creator A5088751229 @default.
• W2897917666 creator A5089546200 @default.
• W2897917666 creator A5089781839 @default.
• W2897917666 date "2018-10-22" @default.
• W2897917666 modified "2023-10-17" @default.
• W2897917666 title "Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease" @default.
• W2897917666 cites W1185701 @default.
• W2897917666 cites W1964895626 @default.
• W2897917666 cites W1966327575 @default.
• W2897917666 cites W1966549856 @default.
• W2897917666 cites W1969149505 @default.
• W2897917666 cites W1969660985 @default.
• W2897917666 cites W1969839871 @default.
• W2897917666 cites W1989960772 @default.
• W2897917666 cites W1999959128 @default.
• W2897917666 cites W2000653200 @default.
• W2897917666 cites W2001837599 @default.
• W2897917666 cites W2005560465 @default.
• W2897917666 cites W2032041622 @default.
• W2897917666 cites W2035682260 @default.
• W2897917666 cites W2039278870 @default.
• W2897917666 cites W2040737306 @default.
• W2897917666 cites W2041586213 @default.
• W2897917666 cites W2043842514 @default.
• W2897917666 cites W2045796854 @default.
• W2897917666 cites W2057960967 @default.
• W2897917666 cites W2061054529 @default.
• W2897917666 cites W2080460005 @default.
• W2897917666 cites W2086021638 @default.
• W2897917666 cites W2086066803 @default.
• W2897917666 cites W2090808827 @default.
• W2897917666 cites W2092175020 @default.
• W2897917666 cites W2093065590 @default.
• W2897917666 cites W2096728243 @default.
• W2897917666 cites W2098555833 @default.
• W2897917666 cites W2099085143 @default.
• W2897917666 cites W2108797218 @default.
• W2897917666 cites W2120244696 @default.
• W2897917666 cites W2120280233 @default.
• W2897917666 cites W2122538288 @default.
• W2897917666 cites W2123168196 @default.
• W2897917666 cites W2130410032 @default.
• W2897917666 cites W2136936290 @default.
• W2897917666 cites W2139294174 @default.
• W2897917666 cites W2139487710 @default.
• W2897917666 cites W2143286837 @default.
• W2897917666 cites W2144086069 @default.
• W2897917666 cites W2150982398 @default.
• W2897917666 cites W2152227081 @default.
• W2897917666 cites W2157955707 @default.
• W2897917666 cites W2158534900 @default.
• W2897917666 cites W2164118055 @default.
• W2897917666 cites W2168526937 @default.
• W2897917666 cites W2169353806 @default.
• W2897917666 cites W2177191094 @default.
• W2897917666 cites W2179438025 @default.
• W2897917666 cites W2200388872 @default.
• W2897917666 cites W2222845006 @default.
• W2897917666 cites W2291173445 @default.
• W2897917666 cites W2294302252 @default.
• W2897917666 cites W2331468358 @default.
• W2897917666 cites W2515459743 @default.
• W2897917666 cites W2545876555 @default.
• W2897917666 cites W2546932883 @default.
• W2897917666 cites W2548971621 @default.
• W2897917666 cites W2592673836 @default.
• W2897917666 cites W2599714772 @default.
• W2897917666 cites W2615304062 @default.
• W2897917666 cites W2745538300 @default.
• W2897917666 cites W2749689006 @default.
• W2897917666 cites W2754510727 @default.
• W2897917666 cites W2784764983 @default.
• W2897917666 cites W2808672726 @default.
• W2897917666 doi "https://doi.org/10.1186/s13293-018-0205-7" @default.
• W2897917666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196429" @default.
• W2897917666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30343673" @default.
• W2897917666 hasPublicationYear "2018" @default.
• W2897917666 type Work @default.
• W2897917666 sameAs 2897917666 @default.
• W2897917666 citedByCount "56" @default.
• W2897917666 countsByYear W28979176662019 @default.
• W2897917666 countsByYear W28979176662020 @default.
• W2897917666 countsByYear W28979176662021 @default.
• W2897917666 countsByYear W28979176662022 @default.
• W2897917666 countsByYear W28979176662023 @default.
• W2897917666 crossrefType "journal-article" @default.
• W2897917666 hasAuthorship W2897917666A5000117288 @default.
• W2897917666 hasAuthorship W2897917666A5016721130 @default.
• W2897917666 hasAuthorship W2897917666A5017019764 @default.
• W2897917666 hasAuthorship W2897917666A5020562578 @default.

• next