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- W2897921907 abstract "Helicobacter pylori is a leading cause of gastric cancer worldwide, its type four secretary toxin CagA is cited to be primarily responsible for it. Other virulence factors such as urease, VacA, HopQ, BabA and SabA are responsible for bacterial survival in acidic environment, adherence and cellular damage but its molecular mechanism is not completely understood. A number of pathogens including bacteria, fungi and virus are involved in the regulation of cellular machinery of inflammasome. Inflammasomes are multimeric protein complexes formed after external stimuli such as PAMPs/DAMPs or salt crystals and activates cellular caspases causes inflammation via pro-inflammatory cytokines. Virulence factors associated with microbial pathogens causes' cellular damage through damaging mitochondria, rupturing lysosome, producing endoplasmic stress and dysregulation of cellular ions balance. These cellular dysfunctioning leads to oxidative stress, cathepsin B production, nuclear and mitochondrial DNA damage which activates inflammasome machinery, pro-inflammatory cytokine release and cellular death known as pyroptosis. The mechanism of inflammasome induction by H. pylori is not studied extensively and very few virulence factors such as UreB, CagA, FlaA and VacA and their role in inflammasomes is established. This review elaborates the mechanism of inflammasomes regulation and elucidates the pathways through which H. pylori regulates inflammasome activation." @default.
- W2897921907 created "2018-10-26" @default.
- W2897921907 creator A5051346065 @default.
- W2897921907 creator A5070579345 @default.
- W2897921907 date "2018-12-01" @default.
- W2897921907 modified "2023-09-26" @default.
- W2897921907 title "Inflammasome activation and regulation during Helicobacter pylori pathogenesis" @default.
- W2897921907 cites W1510180387 @default.
- W2897921907 cites W1750136822 @default.
- W2897921907 cites W1764212712 @default.
- W2897921907 cites W1784630349 @default.
- W2897921907 cites W1864325817 @default.
- W2897921907 cites W1971915082 @default.
- W2897921907 cites W1975213539 @default.
- W2897921907 cites W1987329700 @default.
- W2897921907 cites W1996239744 @default.
- W2897921907 cites W2004447523 @default.
- W2897921907 cites W2007731336 @default.
- W2897921907 cites W2009004909 @default.
- W2897921907 cites W2014579455 @default.
- W2897921907 cites W2015449706 @default.
- W2897921907 cites W2020369401 @default.
- W2897921907 cites W2020683003 @default.
- W2897921907 cites W2043260789 @default.
- W2897921907 cites W2043661964 @default.
- W2897921907 cites W2047923753 @default.
- W2897921907 cites W2050165541 @default.
- W2897921907 cites W2067187611 @default.
- W2897921907 cites W2076286334 @default.
- W2897921907 cites W2079923062 @default.
- W2897921907 cites W2082643302 @default.
- W2897921907 cites W2084158898 @default.
- W2897921907 cites W2087888580 @default.
- W2897921907 cites W2088895400 @default.
- W2897921907 cites W2089003246 @default.
- W2897921907 cites W2090512053 @default.
- W2897921907 cites W2091668211 @default.
- W2897921907 cites W2096095879 @default.
- W2897921907 cites W2097112399 @default.
- W2897921907 cites W2102726155 @default.
- W2897921907 cites W2103200355 @default.
- W2897921907 cites W2107898605 @default.
- W2897921907 cites W2123105952 @default.
- W2897921907 cites W2127453904 @default.
- W2897921907 cites W2128319349 @default.
- W2897921907 cites W2130940574 @default.
- W2897921907 cites W2130983232 @default.
- W2897921907 cites W2144554336 @default.
- W2897921907 cites W2148033744 @default.
- W2897921907 cites W2148795627 @default.
- W2897921907 cites W2148849513 @default.
- W2897921907 cites W2155990940 @default.
- W2897921907 cites W2166680226 @default.
- W2897921907 cites W2168008880 @default.
- W2897921907 cites W2168398643 @default.
- W2897921907 cites W2168564721 @default.
- W2897921907 cites W2181134944 @default.
- W2897921907 cites W2183663489 @default.
- W2897921907 cites W2209731801 @default.
- W2897921907 cites W2210680772 @default.
- W2897921907 cites W2254807163 @default.
- W2897921907 cites W2262933812 @default.
- W2897921907 cites W2267080217 @default.
- W2897921907 cites W2282660831 @default.
- W2897921907 cites W2317348028 @default.
- W2897921907 cites W2320937221 @default.
- W2897921907 cites W2343651708 @default.
- W2897921907 cites W2431987552 @default.
- W2897921907 cites W2516960518 @default.
- W2897921907 cites W2560356992 @default.
- W2897921907 cites W2561943138 @default.
- W2897921907 cites W2564831815 @default.
- W2897921907 cites W2572113648 @default.
- W2897921907 cites W2580681278 @default.
- W2897921907 cites W2609752905 @default.
- W2897921907 cites W2610420640 @default.
- W2897921907 cites W2624735087 @default.
- W2897921907 cites W2685260364 @default.
- W2897921907 cites W2728668609 @default.
- W2897921907 cites W2748076679 @default.
- W2897921907 cites W2748411395 @default.
- W2897921907 cites W2766653494 @default.
- W2897921907 cites W2770777842 @default.
- W2897921907 cites W2773646465 @default.
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- W2897921907 doi "https://doi.org/10.1016/j.micpath.2018.10.012" @default.
- W2897921907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30316008" @default.
- W2897921907 hasPublicationYear "2018" @default.
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