FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897923119> ?p ?o ?g. }

• W2897923119 endingPage "e13896" @default.
• W2897923119 startingPage "e13896" @default.
• W2897923119 abstract "Smooth muscle has a central role in bronchospasm-induced airway obstruction in asthma. Alternative mRNA splicing of the smooth muscle myosin heavy chain (myh11) gene produces four different isoforms, one of which (SMB) is characterized by the inclusion of the exon5b, which doubles the smooth muscle cells contraction velocity. Deciphering the regulation of the expression levels of the SMB isoform would represent a major step for the understanding of the triggers and pathways leading to airway smooth muscle contraction in asthma. Our objective was therefore, to study the splicing regulation mechanisms of the exon5b in airway smooth muscle cells. Bioinformatics analysis was performed to identify the cis-regulatory elements present in the exon5b using HSF finder 3 tool. The expression of the corresponding serine/arginine rich protein (SR) genes thus identified was evaluated by quantitative RT-PCR (qPCR). SRSF1, SRSF6, and hnRNPA1 cis-acting elements were identified by in silico analysis of the exon5b sequence as splicing regulator candidates. QPCR analyses showed that SRSF1 and SRSF6 are upregulated in ASM cells from asthmatic horses in exacerbation (n = 5) compared to controls (n = 5). The inhibition of the identified splicing factors by small interfering RNA allowed identifying the regulation of the SMB isoform by SRSF6. Our results implicate for the first time the upregulation of SRSF6 and SRSF1 in the asthmatic ASM cells and indicate that SRSF6 induces the exon5b inclusion. This study provides an important first step for the understanding of the triggers and pathways leading to ASM hypercontraction and identifies a possible new target for asthma." @default.
• W2897923119 created "2018-10-26" @default.
• W2897923119 creator A5003258141 @default.
• W2897923119 creator A5052878979 @default.
• W2897923119 creator A5062460392 @default.
• W2897923119 creator A5065665641 @default.
• W2897923119 date "2018-10-01" @default.
• W2897923119 modified "2023-10-03" @default.
• W2897923119 title "SRSF6 is upregulated in asthmatic horses and involved in the MYH11 SMB expression" @default.
• W2897923119 cites W1515141336 @default.
• W2897923119 cites W1581643045 @default.
• W2897923119 cites W2002340060 @default.
• W2897923119 cites W2026045779 @default.
• W2897923119 cites W2026657651 @default.
• W2897923119 cites W2041724562 @default.
• W2897923119 cites W2045300068 @default.
• W2897923119 cites W2053348292 @default.
• W2897923119 cites W2058737848 @default.
• W2897923119 cites W2063225252 @default.
• W2897923119 cites W2075361531 @default.
• W2897923119 cites W2076107024 @default.
• W2897923119 cites W2116178342 @default.
• W2897923119 cites W2120423234 @default.
• W2897923119 cites W2126758478 @default.
• W2897923119 cites W2128195632 @default.
• W2897923119 cites W2128404955 @default.
• W2897923119 cites W2137386356 @default.
• W2897923119 cites W2143858946 @default.
• W2897923119 cites W2151078655 @default.
• W2897923119 cites W2163393481 @default.
• W2897923119 cites W2224999195 @default.
• W2897923119 cites W2339400807 @default.
• W2897923119 cites W2466728185 @default.
• W2897923119 cites W2744464063 @default.
• W2897923119 cites W280126174 @default.
• W2897923119 cites W2897923119 @default.
• W2897923119 doi "https://doi.org/10.14814/phy2.13896" @default.
• W2897923119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198134" @default.
• W2897923119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30350466" @default.
• W2897923119 hasPublicationYear "2018" @default.
• W2897923119 type Work @default.
• W2897923119 sameAs 2897923119 @default.
• W2897923119 citedByCount "6" @default.
• W2897923119 countsByYear W28979231192019 @default.
• W2897923119 countsByYear W28979231192020 @default.
• W2897923119 countsByYear W28979231192021 @default.
• W2897923119 countsByYear W28979231192022 @default.
• W2897923119 crossrefType "journal-article" @default.
• W2897923119 hasAuthorship W2897923119A5003258141 @default.
• W2897923119 hasAuthorship W2897923119A5052878979 @default.
• W2897923119 hasAuthorship W2897923119A5062460392 @default.
• W2897923119 hasAuthorship W2897923119A5065665641 @default.
• W2897923119 hasBestOaLocation W28979231191 @default.
• W2897923119 hasConcept C104317684 @default.
• W2897923119 hasConcept C105580179 @default.
• W2897923119 hasConcept C127561419 @default.
• W2897923119 hasConcept C150194340 @default.
• W2897923119 hasConcept C153911025 @default.
• W2897923119 hasConcept C194583182 @default.
• W2897923119 hasConcept C2775905019 @default.
• W2897923119 hasConcept C36823959 @default.
• W2897923119 hasConcept C53345823 @default.
• W2897923119 hasConcept C54355233 @default.
• W2897923119 hasConcept C54458228 @default.
• W2897923119 hasConcept C67705224 @default.
• W2897923119 hasConcept C6997183 @default.
• W2897923119 hasConcept C86803240 @default.
• W2897923119 hasConcept C95444343 @default.
• W2897923119 hasConceptScore W2897923119C104317684 @default.
• W2897923119 hasConceptScore W2897923119C105580179 @default.
• W2897923119 hasConceptScore W2897923119C127561419 @default.
• W2897923119 hasConceptScore W2897923119C150194340 @default.
• W2897923119 hasConceptScore W2897923119C153911025 @default.
• W2897923119 hasConceptScore W2897923119C194583182 @default.
• W2897923119 hasConceptScore W2897923119C2775905019 @default.
• W2897923119 hasConceptScore W2897923119C36823959 @default.
• W2897923119 hasConceptScore W2897923119C53345823 @default.
• W2897923119 hasConceptScore W2897923119C54355233 @default.
• W2897923119 hasConceptScore W2897923119C54458228 @default.
• W2897923119 hasConceptScore W2897923119C67705224 @default.
• W2897923119 hasConceptScore W2897923119C6997183 @default.
• W2897923119 hasConceptScore W2897923119C86803240 @default.
• W2897923119 hasConceptScore W2897923119C95444343 @default.
• W2897923119 hasFunder F4320334506 @default.
• W2897923119 hasIssue "20" @default.
• W2897923119 hasLocation W28979231191 @default.
• W2897923119 hasLocation W28979231192 @default.
• W2897923119 hasLocation W28979231193 @default.
• W2897923119 hasLocation W28979231194 @default.
• W2897923119 hasOpenAccess W2897923119 @default.
• W2897923119 hasPrimaryLocation W28979231191 @default.
• W2897923119 hasRelatedWork W2053656597 @default.
• W2897923119 hasRelatedWork W2060805960 @default.
• W2897923119 hasRelatedWork W2062066078 @default.
• W2897923119 hasRelatedWork W2082798321 @default.
• W2897923119 hasRelatedWork W2083847629 @default.
• W2897923119 hasRelatedWork W2104358039 @default.
• W2897923119 hasRelatedWork W2187198777 @default.

• next