FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897925251> ?p ?o ?g. }

• W2897925251 endingPage "232596711880279" @default.
• W2897925251 startingPage "232596711880279" @default.
• W2897925251 abstract "A major obstacle to the treatment of soft tissue injuries is the hypovascular nature of the tissues. Deferoxamine (DFO) has been shown to stimulate angiogenesis by limiting the degradation of intracellular hypoxia-inducible factor 1-alpha.DFO-saturated suture would induce angiogenesis and improve the markers of early healing in an Achilles tendon repair model.Controlled laboratory study.Broiler hens were randomly assigned to the control (CTL) group or DFO group (n = 9 per group). The right Achilles tendon was partially transected at its middle third. The defect was surgically repaired using 3-0 Vicryl suture soaked in either sterile water (CTL group) or 324 mM DFO solution (DFO group). All animals were euthanized 2 weeks after the injury, and the tendon was harvested. Half of the tendon was used to evaluate angiogenesis via hemoglobin content and tissue repair via DNA content and proteoglycan (PG) content. The other half of the tendon was sectioned and stained with hematoxylin and eosin, safranin O, and lectin to evaluate vessel density.Hemoglobin content (percentage of wet tissue weight) was significantly increased in the DFO group compared with the CTL group (0.081 ± 0.012 vs 0.063 ± 0.016, respectively; P = .046). DNA content (percentage of wet tissue weight) was also significantly increased in the DFO group compared with the CTL group (0.31 ± 0.05 vs 0.23 ± 0.03, respectively; P = .024). PG content (percentage of wet tissue weight) was significantly decreased in the DFO group compared with the CTL group (0.26 ± 0.02 vs 0.33 ± 0.08, respectively; P = .035). Total chondroid area (number of vessels per mm2 of tissue area evaluated) was significantly decreased in the DFO group compared with the CTL group (17.2 ± 6.6 vs 24.6 ± 5.1, respectively; P = .038). Articular zone vessel density (vessels/mm2) was significantly increased in the DFO group compared with the CTL group (7.1 ± 2.5 vs 2.1 ± 0.9, respectively; P = .026).The significant increase in hemoglobin content as well as articular zone vessel density in the DFO group compared with the CTL group is evidence of increased angiogenesis in the fibrocartilaginous region of the tendon exposed to DFO. The DFO group also displayed a significantly greater level of DNA and significantly lower level of PG, suggesting enhanced early healing by fibrous tissue formation.Stimulating angiogenesis by DFO-saturated suture may be clinically useful to improve healing of poorly vascularized tissues." @default.
• W2897925251 created "2018-10-26" @default.
• W2897925251 creator A5003967625 @default.
• W2897925251 creator A5029437900 @default.
• W2897925251 creator A5030308665 @default.
• W2897925251 creator A5060941217 @default.
• W2897925251 creator A5077660075 @default.
• W2897925251 creator A5077701463 @default.
• W2897925251 date "2018-10-01" @default.
• W2897925251 modified "2023-10-16" @default.
• W2897925251 title "Deferoxamine-Soaked Suture Improves Angiogenesis and Repair Potential After Acute Injury of the Chicken Achilles Tendon" @default.
• W2897925251 cites W1534277560 @default.
• W2897925251 cites W1870771671 @default.
• W2897925251 cites W1961578975 @default.
• W2897925251 cites W1983841918 @default.
• W2897925251 cites W20007231 @default.
• W2897925251 cites W2005061205 @default.
• W2897925251 cites W2005574452 @default.
• W2897925251 cites W2006016787 @default.
• W2897925251 cites W2014901911 @default.
• W2897925251 cites W2015642650 @default.
• W2897925251 cites W2022169900 @default.
• W2897925251 cites W2023098909 @default.
• W2897925251 cites W2027519024 @default.
• W2897925251 cites W2030154916 @default.
• W2897925251 cites W2032255522 @default.
• W2897925251 cites W2035469813 @default.
• W2897925251 cites W2039518113 @default.
• W2897925251 cites W2043884900 @default.
• W2897925251 cites W2044206027 @default.
• W2897925251 cites W2052175883 @default.
• W2897925251 cites W2052454749 @default.
• W2897925251 cites W2052774780 @default.
• W2897925251 cites W2065998075 @default.
• W2897925251 cites W2091324157 @default.
• W2897925251 cites W2098315108 @default.
• W2897925251 cites W2099397203 @default.
• W2897925251 cites W2101031305 @default.
• W2897925251 cites W2105389636 @default.
• W2897925251 cites W2130441881 @default.
• W2897925251 cites W2131500169 @default.
• W2897925251 cites W2131811909 @default.
• W2897925251 cites W2133380841 @default.
• W2897925251 cites W2416202799 @default.
• W2897925251 cites W2509593708 @default.
• W2897925251 cites W2528505682 @default.
• W2897925251 cites W2534415341 @default.
• W2897925251 cites W2568908922 @default.
• W2897925251 cites W4243424795 @default.
• W2897925251 doi "https://doi.org/10.1177/2325967118802792" @default.
• W2897925251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6201186" @default.
• W2897925251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30370309" @default.
• W2897925251 hasPublicationYear "2018" @default.
• W2897925251 type Work @default.
• W2897925251 sameAs 2897925251 @default.
• W2897925251 citedByCount "3" @default.
• W2897925251 countsByYear W28979252512022 @default.
• W2897925251 countsByYear W28979252512023 @default.
• W2897925251 crossrefType "journal-article" @default.
• W2897925251 hasAuthorship W2897925251A5003967625 @default.
• W2897925251 hasAuthorship W2897925251A5029437900 @default.
• W2897925251 hasAuthorship W2897925251A5030308665 @default.
• W2897925251 hasAuthorship W2897925251A5060941217 @default.
• W2897925251 hasAuthorship W2897925251A5077660075 @default.
• W2897925251 hasAuthorship W2897925251A5077701463 @default.
• W2897925251 hasBestOaLocation W28979252511 @default.
• W2897925251 hasConcept C126322002 @default.
• W2897925251 hasConcept C141071460 @default.
• W2897925251 hasConcept C16685009 @default.
• W2897925251 hasConcept C2777327002 @default.
• W2897925251 hasConcept C2778271429 @default.
• W2897925251 hasConcept C2780105995 @default.
• W2897925251 hasConcept C2780394083 @default.
• W2897925251 hasConcept C2780984734 @default.
• W2897925251 hasConcept C71924100 @default.
• W2897925251 hasConceptScore W2897925251C126322002 @default.
• W2897925251 hasConceptScore W2897925251C141071460 @default.
• W2897925251 hasConceptScore W2897925251C16685009 @default.
• W2897925251 hasConceptScore W2897925251C2777327002 @default.
• W2897925251 hasConceptScore W2897925251C2778271429 @default.
• W2897925251 hasConceptScore W2897925251C2780105995 @default.
• W2897925251 hasConceptScore W2897925251C2780394083 @default.
• W2897925251 hasConceptScore W2897925251C2780984734 @default.
• W2897925251 hasConceptScore W2897925251C71924100 @default.
• W2897925251 hasIssue "10" @default.
• W2897925251 hasLocation W28979252511 @default.
• W2897925251 hasLocation W28979252512 @default.
• W2897925251 hasLocation W28979252513 @default.
• W2897925251 hasLocation W28979252514 @default.
• W2897925251 hasOpenAccess W2897925251 @default.
• W2897925251 hasPrimaryLocation W28979252511 @default.
• W2897925251 hasRelatedWork W2038834124 @default.
• W2897925251 hasRelatedWork W2046203810 @default.
• W2897925251 hasRelatedWork W2223076784 @default.
• W2897925251 hasRelatedWork W2353021223 @default.
• W2897925251 hasRelatedWork W2378055574 @default.
• W2897925251 hasRelatedWork W2412618101 @default.
• W2897925251 hasRelatedWork W2590382824 @default.

• next