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- W2897928794 abstract "A phytochemical investigation of the stem barks of the Malaysian Croton oblongus Burm.f. (Syn. Croton laevifolius Blume) (Euphorbiaceae) yielded seven previously undescribed ent-neo-clerodane diterpenoids, laevifins A - G and the known crovatin (3). Structures were established by a combination of spectroscopic methods including HRESIMS, NMR spectroscopy and X-ray crystallography. The absolute configuration of crovatin and laevifins A-G was established by comparison of experimental ECD and theoretical TDDFT ECD calculated spectra. This is the first report on the occurrence of the sesquiterpenoid cryptomeridiol in a Croton species. In vitro cytotoxicity assays on laevifins A, B and G showed moderate activities against the MCF-7 cancer cell line (IC50 102, 115 and 106 μM, respectively) while β-amyrin and acetyl aleuritolic acid showed good anti-inflammatory activity on the LPS-induced NF-κB translocation inhibition in RAW 264.7 cells assay with IC50 values of 23.5 and 35.4 μg/mL, respectively." @default.
- W2897928794 created "2018-10-26" @default.
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- W2897928794 date "2018-12-01" @default.
- W2897928794 modified "2023-10-18" @default.
- W2897928794 title "Laevifins A–G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f." @default.
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- W2897928794 doi "https://doi.org/10.1016/j.phytochem.2018.10.002" @default.
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