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- W2897934356 abstract "Abstract Myeloproliferative neoplasms ( MPN ) are defined by clonal expansion of hematopoietic progenitor cells and often associated with systemic thrombosis. Arterial thrombi due to MPN have a multifactorial etiology and are typically managed with antiplatelet agents. However, recent mechanistic studies on patients with JAK 2V617F mutations have demonstrated alterations in cellular heparanase activity that results in a hypercoagulable state. We report a patient with MPN presenting with acute ischemic stroke caused by a basilar artery thrombus due to JAK 2V617F mutation related hypercoagulability. Newer direct oral anticoagulants may be appropriate for secondary stroke prevention in such cases." @default.
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- W2897934356 date "2018-11-14" @default.
- W2897934356 modified "2023-09-27" @default.
- W2897934356 title "Acute ischemic stroke in myeloproliferative neoplasia: Using molecular pathophysiology knowledge to treat prothrombotic state with direct oral anticoagulants" @default.
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- W2897934356 doi "https://doi.org/10.1111/ncn3.12248" @default.
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