FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897936701> ?p ?o ?g. }

• W2897936701 endingPage "217" @default.
• W2897936701 startingPage "197" @default.
• W2897936701 abstract "Multiple studies have demonstrated the utility of chromosomal microarray (CMA) testing to identify clinically significant copy number alterations (CNAs) and copy-neutral loss-of-heterozygosity (CN-LOH) in myeloid malignancies. However, guidelines for integrating CMA as a standard practice for diagnostic evaluation, assessment of prognosis and predicting treatment response are still lacking. CMA has not been recommended for clinical work-up of myeloid malignancies by the WHO 2016 or the NCCN 2017 guidelines but is a suggested test by the European LeukaemiaNet 2013 for the diagnosis of primary myelodysplastic syndrome (MDS). The Cancer Genomics Consortium (CGC) Working Group for Myeloid Neoplasms systematically reviewed peer-reviewed literature to determine the power of CMA in (1) improving diagnostic yield, (2) refining risk stratification, and (3) providing additional genomic information to guide therapy. In this manuscript, we summarize the evidence base for the clinical utility of array testing in the workup of MDS, myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and myeloproliferative neoplasms (MPN). This review provides a list of recurrent CNAs and CN-LOH noted in this disease spectrum and describes the clinical significance of the aberrations and how they complement gene mutation findings by sequencing. Furthermore, for new or suspected diagnosis of MDS or MPN, we present suggestions for integrating genomic testing methods (CMA and mutation testing by next generation sequencing) into the current standard-of-care clinical laboratory testing (karyotype, FISH, morphology, and flow)." @default.
• W2897936701 created "2018-10-26" @default.
• W2897936701 creator A5002611478 @default.
• W2897936701 creator A5005959019 @default.
• W2897936701 creator A5026614628 @default.
• W2897936701 creator A5032073548 @default.
• W2897936701 creator A5037972294 @default.
• W2897936701 creator A5038296860 @default.
• W2897936701 creator A5042991227 @default.
• W2897936701 creator A5045975673 @default.
• W2897936701 creator A5047620115 @default.
• W2897936701 creator A5057465226 @default.
• W2897936701 creator A5059373442 @default.
• W2897936701 creator A5068661649 @default.
• W2897936701 creator A5069100135 @default.
• W2897936701 creator A5073052072 @default.
• W2897936701 creator A5073322251 @default.
• W2897936701 creator A5082380726 @default.
• W2897936701 creator A5089936608 @default.
• W2897936701 date "2018-12-01" @default.
• W2897936701 modified "2023-10-01" @default.
• W2897936701 title "Assessing copy number aberrations and copy neutral loss of heterozygosity across the genome as best practice: An evidence based review of clinical utility from the cancer genomics consortium (CGC) working group for myelodysplastic syndrome, myelodysplastic/myeloproliferative and myeloproliferative neoplasms" @default.
• W2897936701 cites W1559341351 @default.
• W2897936701 cites W1560869622 @default.
• W2897936701 cites W1580833069 @default.
• W2897936701 cites W1824128704 @default.
• W2897936701 cites W187238933 @default.
• W2897936701 cites W1895073854 @default.
• W2897936701 cites W1935562803 @default.
• W2897936701 cites W1940917947 @default.
• W2897936701 cites W1964809738 @default.
• W2897936701 cites W1964855123 @default.
• W2897936701 cites W1966149362 @default.
• W2897936701 cites W1967187400 @default.
• W2897936701 cites W1970375103 @default.
• W2897936701 cites W1970579944 @default.
• W2897936701 cites W1972420606 @default.
• W2897936701 cites W1974842446 @default.
• W2897936701 cites W1975546972 @default.
• W2897936701 cites W1976529806 @default.
• W2897936701 cites W1977724926 @default.
• W2897936701 cites W1980568348 @default.
• W2897936701 cites W1983602304 @default.
• W2897936701 cites W1984567268 @default.
• W2897936701 cites W1985761271 @default.
• W2897936701 cites W1985823023 @default.
• W2897936701 cites W1988633385 @default.
• W2897936701 cites W1992826811 @default.
• W2897936701 cites W1993236149 @default.
• W2897936701 cites W1993455476 @default.
• W2897936701 cites W1994924914 @default.
• W2897936701 cites W1995505548 @default.
• W2897936701 cites W1996100423 @default.
• W2897936701 cites W2003262852 @default.
• W2897936701 cites W2003615647 @default.
• W2897936701 cites W2004237422 @default.
• W2897936701 cites W2006254364 @default.
• W2897936701 cites W2009854509 @default.
• W2897936701 cites W2012686883 @default.
• W2897936701 cites W2012945687 @default.
• W2897936701 cites W2013398180 @default.
• W2897936701 cites W2015568081 @default.
• W2897936701 cites W2016230247 @default.
• W2897936701 cites W2028171870 @default.
• W2897936701 cites W2032487024 @default.
• W2897936701 cites W2032703975 @default.
• W2897936701 cites W2037178130 @default.
• W2897936701 cites W2038449950 @default.
• W2897936701 cites W2039234691 @default.
• W2897936701 cites W2046562108 @default.
• W2897936701 cites W2049461277 @default.
• W2897936701 cites W2050449741 @default.
• W2897936701 cites W2051293191 @default.
• W2897936701 cites W2056477482 @default.
• W2897936701 cites W2059130068 @default.
• W2897936701 cites W2059318094 @default.
• W2897936701 cites W2059497670 @default.
• W2897936701 cites W2059852420 @default.
• W2897936701 cites W2066242053 @default.
• W2897936701 cites W2071128187 @default.
• W2897936701 cites W2076142320 @default.
• W2897936701 cites W2076506261 @default.
• W2897936701 cites W2078294866 @default.
• W2897936701 cites W2079049316 @default.
• W2897936701 cites W2081895311 @default.
• W2897936701 cites W2082312262 @default.
• W2897936701 cites W2083109253 @default.
• W2897936701 cites W2083460631 @default.
• W2897936701 cites W2085404468 @default.
• W2897936701 cites W2086029676 @default.
• W2897936701 cites W2086066062 @default.
• W2897936701 cites W2095066915 @default.
• W2897936701 cites W2095855727 @default.
• W2897936701 cites W2100077440 @default.
• W2897936701 cites W2100313064 @default.
• W2897936701 cites W2104086696 @default.
• W2897936701 cites W2106763604 @default.
• W2897936701 cites W2107551895 @default.

• next