FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897937423> ?p ?o ?g. }

• W2897937423 endingPage "142" @default.
• W2897937423 startingPage "135" @default.
• W2897937423 abstract "The pharmacokinetics (PK) and pharmacodynamics of many oral antidepressants (OADs) vary substantially among different genders and ethnicities. Likewise is their therapeutic effectiveness, time to response and the incidence of adverse drug events. The aim of this study is to compare the PK of four OADs (desvenlafaxine; DSV, venlafaxine; VLX, escitalopram; ESP, and agomelatine; AGT) among Egyptian males and females. In this study, LC-MS/MS methods were developed and validated for determining the four OADs in human plasma. Samples were prepared by liquid-liquid extraction. Chromatographic separation was performed on reversed-phase C18 columns followed by positive-ion electrospray ionization and MS/MS detection. The assays were applied for the assessment of PK parameters in human volunteers (n = 95). The developed methods were linear, accurate, and precise for the determination of DSV, VLX, ESP and AGT with extraction recovery of 90 ± 2.0, 98 ± 1.0, 90 ± 1.3 and 87 ± 4.3%, respectively. OADs levels were successfully measured in subjects' plasma and PK parameters were calculated. A prevalent inter-individual variation in PK of the studied OAD was observed. The PK profile of DSV, VLX or ESP did not vary significantly between male and female subjects (p = 0.07–0.98; confidence level (CL) = 95) while the PK of AGT exhibited a significant gender-based variation in both the Cmax and the AUC∞ (p = 0.047 and 0.0015; CL = 95). Our results highlight the significance of therapeutic drug monitoring of OADs. Further, it indicates the dose adjustment based on gender difference may not be relevant for DSV, VLX and ESP while it may be considered for AGT." @default.
• W2897937423 created "2018-10-26" @default.
• W2897937423 creator A5010673741 @default.
• W2897937423 creator A5047104989 @default.
• W2897937423 creator A5089587821 @default.
• W2897937423 date "2018-12-01" @default.
• W2897937423 modified "2023-09-24" @default.
• W2897937423 title "Optimized bio-analytical methods development and comparative pharmacokinetic studies of four antidepressants in Egyptian population based on gender difference" @default.
• W2897937423 cites W106465623 @default.
• W2897937423 cites W1604974677 @default.
• W2897937423 cites W1946216731 @default.
• W2897937423 cites W1972775745 @default.
• W2897937423 cites W1974139348 @default.
• W2897937423 cites W1993107786 @default.
• W2897937423 cites W1995918433 @default.
• W2897937423 cites W2019939591 @default.
• W2897937423 cites W2021292938 @default.
• W2897937423 cites W2043367199 @default.
• W2897937423 cites W2065778846 @default.
• W2897937423 cites W2078322241 @default.
• W2897937423 cites W2078475150 @default.
• W2897937423 cites W2080820439 @default.
• W2897937423 cites W2085390603 @default.
• W2897937423 cites W2097197088 @default.
• W2897937423 cites W2106894252 @default.
• W2897937423 cites W2113278271 @default.
• W2897937423 cites W2128362495 @default.
• W2897937423 cites W2141207311 @default.
• W2897937423 cites W2162390880 @default.
• W2897937423 cites W2175551691 @default.
• W2897937423 cites W2178275521 @default.
• W2897937423 cites W2185690142 @default.
• W2897937423 cites W2187400258 @default.
• W2897937423 cites W2394119497 @default.
• W2897937423 cites W2532792660 @default.
• W2897937423 cites W2554643912 @default.
• W2897937423 cites W2561227170 @default.
• W2897937423 cites W2775447920 @default.
• W2897937423 cites W2788337440 @default.
• W2897937423 cites W2791558269 @default.
• W2897937423 cites W2800137807 @default.
• W2897937423 cites W4367435879 @default.
• W2897937423 doi "https://doi.org/10.1016/j.jchromb.2018.10.018" @default.
• W2897937423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30388703" @default.
• W2897937423 hasPublicationYear "2018" @default.
• W2897937423 type Work @default.
• W2897937423 sameAs 2897937423 @default.
• W2897937423 citedByCount "2" @default.
• W2897937423 countsByYear W28979374232021 @default.
• W2897937423 countsByYear W28979374232022 @default.
• W2897937423 crossrefType "journal-article" @default.
• W2897937423 hasAuthorship W2897937423A5010673741 @default.
• W2897937423 hasAuthorship W2897937423A5047104989 @default.
• W2897937423 hasAuthorship W2897937423A5089587821 @default.
• W2897937423 hasConcept C111113717 @default.
• W2897937423 hasConcept C112705442 @default.
• W2897937423 hasConcept C126322002 @default.
• W2897937423 hasConcept C162356407 @default.
• W2897937423 hasConcept C185592680 @default.
• W2897937423 hasConcept C22979827 @default.
• W2897937423 hasConcept C2776466888 @default.
• W2897937423 hasConcept C2779177272 @default.
• W2897937423 hasConcept C2781161787 @default.
• W2897937423 hasConcept C2908647359 @default.
• W2897937423 hasConcept C40684141 @default.
• W2897937423 hasConcept C43617362 @default.
• W2897937423 hasConcept C44249647 @default.
• W2897937423 hasConcept C4725764 @default.
• W2897937423 hasConcept C71924100 @default.
• W2897937423 hasConcept C98274493 @default.
• W2897937423 hasConcept C99454951 @default.
• W2897937423 hasConceptScore W2897937423C111113717 @default.
• W2897937423 hasConceptScore W2897937423C112705442 @default.
• W2897937423 hasConceptScore W2897937423C126322002 @default.
• W2897937423 hasConceptScore W2897937423C162356407 @default.
• W2897937423 hasConceptScore W2897937423C185592680 @default.
• W2897937423 hasConceptScore W2897937423C22979827 @default.
• W2897937423 hasConceptScore W2897937423C2776466888 @default.
• W2897937423 hasConceptScore W2897937423C2779177272 @default.
• W2897937423 hasConceptScore W2897937423C2781161787 @default.
• W2897937423 hasConceptScore W2897937423C2908647359 @default.
• W2897937423 hasConceptScore W2897937423C40684141 @default.
• W2897937423 hasConceptScore W2897937423C43617362 @default.
• W2897937423 hasConceptScore W2897937423C44249647 @default.
• W2897937423 hasConceptScore W2897937423C4725764 @default.
• W2897937423 hasConceptScore W2897937423C71924100 @default.
• W2897937423 hasConceptScore W2897937423C98274493 @default.
• W2897937423 hasConceptScore W2897937423C99454951 @default.
• W2897937423 hasLocation W28979374231 @default.
• W2897937423 hasLocation W28979374232 @default.
• W2897937423 hasOpenAccess W2897937423 @default.
• W2897937423 hasPrimaryLocation W28979374231 @default.
• W2897937423 hasRelatedWork W1541103017 @default.
• W2897937423 hasRelatedWork W1997101420 @default.
• W2897937423 hasRelatedWork W2000547109 @default.
• W2897937423 hasRelatedWork W2158380752 @default.
• W2897937423 hasRelatedWork W2477866235 @default.
• W2897937423 hasRelatedWork W2617001846 @default.

• next