Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897938130> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2897938130 endingPage "398" @default.
- W2897938130 startingPage "395" @default.
- W2897938130 abstract "The objective of this study is to describe the pharmacokinetics of lacosamide in a critically ill adult during continuous venovenous hemofiltration (CVVH). A 78-year-old male developed sepsis and acute kidney injury following cardiac surgery. He was initially treated with intermittent hemodialysis but developed nonconvulsive status epilepticus at the end of the first session and was subsequently initiated on CVVH. In addition to lorazepam boluses, levetiracetam, and midazolam infusion, he was loaded with lacosamide 400 mg intravenously and started on 200 mg intravenously twice daily as maintenance therapy. Noncompartmental modeling of lacosamide pharmacokinetics revealed significant extracorporeal removal, a volume of distribution of 0.69 L/kg, elimination half-life of 13.6 hours, and peak and trough concentrations of 7.4 and 3.7 mg/L, respectively (goal trough, 5-10 mg/L). We found significant extracorporeal removal of serum lacosamide during CVVH, which was higher than previously reported. This led to subtherapeutic concentrations and decreased overall antiepileptic drug exposure. The relationship between serum lacosamide concentrations and clinical efficacy is not well understood; thus, therapeutic drug monitoring is not routinely recommended. Yet, we demonstrated that measuring serum lacosamide concentrations in the critically ill population during continuous renal replacement therapy may be useful to individualize dosing programs. Further pharmacokinetic studies of lacosamide may be necessary to generate widespread dosing recommendations." @default.
- W2897938130 created "2018-10-26" @default.
- W2897938130 creator A5019678346 @default.
- W2897938130 creator A5025259402 @default.
- W2897938130 creator A5040329994 @default.
- W2897938130 creator A5060197397 @default.
- W2897938130 creator A5082626550 @default.
- W2897938130 date "2018-10-18" @default.
- W2897938130 modified "2023-09-23" @default.
- W2897938130 title "Lacosamide Pharmacokinetics in a Critically Ill Patient During Continuous Renal Replacement Therapy" @default.
- W2897938130 cites W1939420309 @default.
- W2897938130 cites W2012335416 @default.
- W2897938130 cites W2058959672 @default.
- W2897938130 cites W2157089674 @default.
- W2897938130 cites W2396559747 @default.
- W2897938130 cites W2536269490 @default.
- W2897938130 cites W2768596428 @default.
- W2897938130 cites W311067477 @default.
- W2897938130 doi "https://doi.org/10.1177/0897190018803765" @default.
- W2897938130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30336720" @default.
- W2897938130 hasPublicationYear "2018" @default.
- W2897938130 type Work @default.
- W2897938130 sameAs 2897938130 @default.
- W2897938130 citedByCount "7" @default.
- W2897938130 countsByYear W28979381302020 @default.
- W2897938130 countsByYear W28979381302021 @default.
- W2897938130 countsByYear W28979381302022 @default.
- W2897938130 crossrefType "journal-article" @default.
- W2897938130 hasAuthorship W2897938130A5019678346 @default.
- W2897938130 hasAuthorship W2897938130A5025259402 @default.
- W2897938130 hasAuthorship W2897938130A5040329994 @default.
- W2897938130 hasAuthorship W2897938130A5060197397 @default.
- W2897938130 hasAuthorship W2897938130A5082626550 @default.
- W2897938130 hasConcept C111113717 @default.
- W2897938130 hasConcept C112705442 @default.
- W2897938130 hasConcept C118552586 @default.
- W2897938130 hasConcept C126322002 @default.
- W2897938130 hasConcept C139254425 @default.
- W2897938130 hasConcept C177713679 @default.
- W2897938130 hasConcept C2777288759 @default.
- W2897938130 hasConcept C2777332695 @default.
- W2897938130 hasConcept C2777341932 @default.
- W2897938130 hasConcept C2778063415 @default.
- W2897938130 hasConcept C2778139780 @default.
- W2897938130 hasConcept C2778186239 @default.
- W2897938130 hasConcept C2778865887 @default.
- W2897938130 hasConcept C2779541074 @default.
- W2897938130 hasConcept C2779915274 @default.
- W2897938130 hasConcept C2780272996 @default.
- W2897938130 hasConcept C2908647359 @default.
- W2897938130 hasConcept C42219234 @default.
- W2897938130 hasConcept C71924100 @default.
- W2897938130 hasConcept C98274493 @default.
- W2897938130 hasConcept C99454951 @default.
- W2897938130 hasConceptScore W2897938130C111113717 @default.
- W2897938130 hasConceptScore W2897938130C112705442 @default.
- W2897938130 hasConceptScore W2897938130C118552586 @default.
- W2897938130 hasConceptScore W2897938130C126322002 @default.
- W2897938130 hasConceptScore W2897938130C139254425 @default.
- W2897938130 hasConceptScore W2897938130C177713679 @default.
- W2897938130 hasConceptScore W2897938130C2777288759 @default.
- W2897938130 hasConceptScore W2897938130C2777332695 @default.
- W2897938130 hasConceptScore W2897938130C2777341932 @default.
- W2897938130 hasConceptScore W2897938130C2778063415 @default.
- W2897938130 hasConceptScore W2897938130C2778139780 @default.
- W2897938130 hasConceptScore W2897938130C2778186239 @default.
- W2897938130 hasConceptScore W2897938130C2778865887 @default.
- W2897938130 hasConceptScore W2897938130C2779541074 @default.
- W2897938130 hasConceptScore W2897938130C2779915274 @default.
- W2897938130 hasConceptScore W2897938130C2780272996 @default.
- W2897938130 hasConceptScore W2897938130C2908647359 @default.
- W2897938130 hasConceptScore W2897938130C42219234 @default.
- W2897938130 hasConceptScore W2897938130C71924100 @default.
- W2897938130 hasConceptScore W2897938130C98274493 @default.
- W2897938130 hasConceptScore W2897938130C99454951 @default.
- W2897938130 hasIssue "3" @default.
- W2897938130 hasLocation W28979381301 @default.
- W2897938130 hasOpenAccess W2897938130 @default.
- W2897938130 hasPrimaryLocation W28979381301 @default.
- W2897938130 hasRelatedWork W2066608027 @default.
- W2897938130 hasRelatedWork W2078896287 @default.
- W2897938130 hasRelatedWork W2770971381 @default.
- W2897938130 hasRelatedWork W2897938130 @default.
- W2897938130 hasRelatedWork W3089571058 @default.
- W2897938130 hasRelatedWork W3187598535 @default.
- W2897938130 hasRelatedWork W3208037690 @default.
- W2897938130 hasRelatedWork W4319598469 @default.
- W2897938130 hasRelatedWork W4385264709 @default.
- W2897938130 hasRelatedWork W4385274271 @default.
- W2897938130 hasVolume "33" @default.
- W2897938130 isParatext "false" @default.
- W2897938130 isRetracted "false" @default.
- W2897938130 magId "2897938130" @default.
- W2897938130 workType "article" @default.