FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897945980> ?p ?o ?g. }

• W2897945980 endingPage "1349" @default.
• W2897945980 startingPage "1340" @default.
• W2897945980 abstract "Berberine (BBR), the major isoquinoline alkaloid in Chinese herb Rhizoma coptidis, has significant lipid-lowering effect by upregulating hepatic low-density lipoprotein receptor (LDLR) expression. In a previous study, we have indicated that berberrubine (M3), a major metabolite of BBR in vivo, displays the most potential hypolipidemic effects via upregulating LDLR expression in human hepatoma (HepG2) cells compared with BBR and 3 other metabolites. Accordingly, 9 M3 analogs (A1-A9) were modified at the C9 position. We aimed to find a new promising agent by evaluating the cholesterol-lowering effect and clarifying the related molecular mechanism. In the current study, the cellular cholesterol content was assayed with a commercial cholesterol assay kit. Real-time polymerase chain reaction and Western blot assay were used to explore the molecular mechanism of M3 and its analogs on the hypolipidemic effect. Among M3 and its analogs, hydroxypropyl-berberrubine (A8) exhibited the highest potential effects on the upregulation of LDLR expression, which was accompanied by a steady decline of proprotein convertase subtilisin/kexin type 9 (PCSK9) messenger RNA and protein levels. Furthermore, inhibition of extracellular signal-regulated kinase (ERK) activity with PD98059 prevented the upregulation of LDLR and downregulation of PCSK9 induced by A8. The current study revealed that M3 and its structurally modified analog, A8, could regulate hepatic LDLR and PCSK9 expression to exert lipid-lowering effects via the ERK signal pathway, while A8 showed a stronger effect and might be a promising drug candidate against hyperlipidemia." @default.
• W2897945980 created "2018-10-26" @default.
• W2897945980 creator A5006936262 @default.
• W2897945980 creator A5015998327 @default.
• W2897945980 creator A5016986169 @default.
• W2897945980 creator A5028428278 @default.
• W2897945980 creator A5036554056 @default.
• W2897945980 creator A5044301848 @default.
• W2897945980 creator A5057735394 @default.
• W2897945980 creator A5088372150 @default.
• W2897945980 date "2018-10-18" @default.
• W2897945980 modified "2023-10-18" @default.
• W2897945980 title "Berberrubine and its analog, hydroxypropyl‐berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol‐lowering effects in human hepatoma HepG2 cells" @default.
• W2897945980 cites W1775255718 @default.
• W2897945980 cites W1901163999 @default.
• W2897945980 cites W1965676778 @default.
• W2897945980 cites W1973195425 @default.
• W2897945980 cites W1976833660 @default.
• W2897945980 cites W1977854052 @default.
• W2897945980 cites W1981847080 @default.
• W2897945980 cites W2000157104 @default.
• W2897945980 cites W2003544964 @default.
• W2897945980 cites W2003808729 @default.
• W2897945980 cites W2005922901 @default.
• W2897945980 cites W2011573311 @default.
• W2897945980 cites W2011857098 @default.
• W2897945980 cites W2011907220 @default.
• W2897945980 cites W2013982259 @default.
• W2897945980 cites W2014547584 @default.
• W2897945980 cites W2028004589 @default.
• W2897945980 cites W2031594806 @default.
• W2897945980 cites W2035099895 @default.
• W2897945980 cites W2040612932 @default.
• W2897945980 cites W2045315353 @default.
• W2897945980 cites W2045995934 @default.
• W2897945980 cites W2050831937 @default.
• W2897945980 cites W2059210927 @default.
• W2897945980 cites W2064994526 @default.
• W2897945980 cites W2067539811 @default.
• W2897945980 cites W2068214309 @default.
• W2897945980 cites W2071154679 @default.
• W2897945980 cites W2073953472 @default.
• W2897945980 cites W2076359557 @default.
• W2897945980 cites W2086508705 @default.
• W2897945980 cites W2088499793 @default.
• W2897945980 cites W2089605820 @default.
• W2897945980 cites W2091571409 @default.
• W2897945980 cites W2118868005 @default.
• W2897945980 cites W2121209370 @default.
• W2897945980 cites W2122864632 @default.
• W2897945980 cites W2127729207 @default.
• W2897945980 cites W2127780525 @default.
• W2897945980 cites W2129582474 @default.
• W2897945980 cites W2132279891 @default.
• W2897945980 cites W2135424573 @default.
• W2897945980 cites W2138486337 @default.
• W2897945980 cites W2141191772 @default.
• W2897945980 cites W2146540050 @default.
• W2897945980 cites W2148156003 @default.
• W2897945980 cites W2156116824 @default.
• W2897945980 cites W2159216465 @default.
• W2897945980 cites W2170467167 @default.
• W2897945980 doi "https://doi.org/10.1002/jcb.27102" @default.
• W2897945980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30335889" @default.
• W2897945980 hasPublicationYear "2018" @default.
• W2897945980 type Work @default.
• W2897945980 sameAs 2897945980 @default.
• W2897945980 citedByCount "23" @default.
• W2897945980 countsByYear W28979459802019 @default.
• W2897945980 countsByYear W28979459802020 @default.
• W2897945980 countsByYear W28979459802021 @default.
• W2897945980 countsByYear W28979459802022 @default.
• W2897945980 countsByYear W28979459802023 @default.
• W2897945980 crossrefType "journal-article" @default.
• W2897945980 hasAuthorship W2897945980A5006936262 @default.
• W2897945980 hasAuthorship W2897945980A5015998327 @default.
• W2897945980 hasAuthorship W2897945980A5016986169 @default.
• W2897945980 hasAuthorship W2897945980A5028428278 @default.
• W2897945980 hasAuthorship W2897945980A5036554056 @default.
• W2897945980 hasAuthorship W2897945980A5044301848 @default.
• W2897945980 hasAuthorship W2897945980A5057735394 @default.
• W2897945980 hasAuthorship W2897945980A5088372150 @default.
• W2897945980 hasConcept C104317684 @default.
• W2897945980 hasConcept C127561419 @default.
• W2897945980 hasConcept C185592680 @default.
• W2897945980 hasConcept C2778163477 @default.
• W2897945980 hasConcept C2778849439 @default.
• W2897945980 hasConcept C2780072125 @default.
• W2897945980 hasConcept C2780116568 @default.
• W2897945980 hasConcept C2780948078 @default.
• W2897945980 hasConcept C43554185 @default.
• W2897945980 hasConcept C55493867 @default.
• W2897945980 hasConcept C57074206 @default.
• W2897945980 hasConcept C62478195 @default.
• W2897945980 hasConcept C86803240 @default.
• W2897945980 hasConcept C95444343 @default.
• W2897945980 hasConcept C98274493 @default.
• W2897945980 hasConceptScore W2897945980C104317684 @default.

• next