Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897950504> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2897950504 abstract "Molecular dynamics of alpha ndash synuclein in the presence of five different salt concentrations show that Zn enhanced the stability of the protein monomer while K shows opposite effect Higher regions of alpha synuclein unfolding was seen between the residues in the presence of NaCl and KCl while the presence of CaCl and MgCl results in similar unfolding between the residues In contrast the unfolding of alpha synuclein in the presence of ZnCl deviate from other salts indicating the influence of Zn in the unfolding of the secondary and tertiary structures of alpha synuclein In protein dimers these misfolding of alpha synuclein are commonly seen between the residues in all these five salts indicating that the NAC region of the dimer is mainly involved in protein unfolding Mutation of Ala Pro clearly shows that decreased the stability of alpha synuclein monomer while Ca influenced protein aggregation in protein dimer Removing the residues from reduced the stability of monomer in the presence of K while shows higher stability with Ca in the protein dimer However both Na and Miens show variations in different forms of the protein These results show that alpha synuclein is less prone to aggregation in the presence of Zn which may have implications for the prevention and therapeutics of the Parkinson rsquo s disease" @default.
- W2897950504 created "2018-10-26" @default.
- W2897950504 creator A5020982051 @default.
- W2897950504 date "2018-04-18" @default.
- W2897950504 modified "2023-09-23" @default.
- W2897950504 title "Insights into the misfolding of ‒synuclein in the presence of metal ions: a simulation study" @default.
- W2897950504 doi "https://doi.org/10.15406/mojddt.2018.02.00030" @default.
- W2897950504 hasPublicationYear "2018" @default.
- W2897950504 type Work @default.
- W2897950504 sameAs 2897950504 @default.
- W2897950504 citedByCount "0" @default.
- W2897950504 crossrefType "journal-article" @default.
- W2897950504 hasAuthorship W2897950504A5020982051 @default.
- W2897950504 hasBestOaLocation W28979505041 @default.
- W2897950504 hasConcept C12554922 @default.
- W2897950504 hasConcept C136238340 @default.
- W2897950504 hasConcept C142724271 @default.
- W2897950504 hasConcept C147597530 @default.
- W2897950504 hasConcept C159110408 @default.
- W2897950504 hasConcept C166940927 @default.
- W2897950504 hasConcept C178790620 @default.
- W2897950504 hasConcept C185592680 @default.
- W2897950504 hasConcept C204328495 @default.
- W2897950504 hasConcept C2775944032 @default.
- W2897950504 hasConcept C2779134260 @default.
- W2897950504 hasConcept C2779546866 @default.
- W2897950504 hasConcept C2779734285 @default.
- W2897950504 hasConcept C2781449126 @default.
- W2897950504 hasConcept C47701112 @default.
- W2897950504 hasConcept C49453240 @default.
- W2897950504 hasConcept C521977710 @default.
- W2897950504 hasConcept C55493867 @default.
- W2897950504 hasConcept C59593255 @default.
- W2897950504 hasConcept C64943373 @default.
- W2897950504 hasConcept C71924100 @default.
- W2897950504 hasConcept C75599170 @default.
- W2897950504 hasConcept C8010536 @default.
- W2897950504 hasConcept C86803240 @default.
- W2897950504 hasConceptScore W2897950504C12554922 @default.
- W2897950504 hasConceptScore W2897950504C136238340 @default.
- W2897950504 hasConceptScore W2897950504C142724271 @default.
- W2897950504 hasConceptScore W2897950504C147597530 @default.
- W2897950504 hasConceptScore W2897950504C159110408 @default.
- W2897950504 hasConceptScore W2897950504C166940927 @default.
- W2897950504 hasConceptScore W2897950504C178790620 @default.
- W2897950504 hasConceptScore W2897950504C185592680 @default.
- W2897950504 hasConceptScore W2897950504C204328495 @default.
- W2897950504 hasConceptScore W2897950504C2775944032 @default.
- W2897950504 hasConceptScore W2897950504C2779134260 @default.
- W2897950504 hasConceptScore W2897950504C2779546866 @default.
- W2897950504 hasConceptScore W2897950504C2779734285 @default.
- W2897950504 hasConceptScore W2897950504C2781449126 @default.
- W2897950504 hasConceptScore W2897950504C47701112 @default.
- W2897950504 hasConceptScore W2897950504C49453240 @default.
- W2897950504 hasConceptScore W2897950504C521977710 @default.
- W2897950504 hasConceptScore W2897950504C55493867 @default.
- W2897950504 hasConceptScore W2897950504C59593255 @default.
- W2897950504 hasConceptScore W2897950504C64943373 @default.
- W2897950504 hasConceptScore W2897950504C71924100 @default.
- W2897950504 hasConceptScore W2897950504C75599170 @default.
- W2897950504 hasConceptScore W2897950504C8010536 @default.
- W2897950504 hasConceptScore W2897950504C86803240 @default.
- W2897950504 hasIssue "2" @default.
- W2897950504 hasLocation W28979505041 @default.
- W2897950504 hasLocation W28979505042 @default.
- W2897950504 hasOpenAccess W2897950504 @default.
- W2897950504 hasPrimaryLocation W28979505041 @default.
- W2897950504 hasRelatedWork W1916157122 @default.
- W2897950504 hasRelatedWork W1973583304 @default.
- W2897950504 hasRelatedWork W1974591061 @default.
- W2897950504 hasRelatedWork W1984609175 @default.
- W2897950504 hasRelatedWork W1999243747 @default.
- W2897950504 hasRelatedWork W2013226867 @default.
- W2897950504 hasRelatedWork W2020446183 @default.
- W2897950504 hasRelatedWork W2074514515 @default.
- W2897950504 hasRelatedWork W2090022092 @default.
- W2897950504 hasRelatedWork W2149434585 @default.
- W2897950504 hasRelatedWork W2164939816 @default.
- W2897950504 hasRelatedWork W2327241638 @default.
- W2897950504 hasRelatedWork W2413992022 @default.
- W2897950504 hasRelatedWork W2464123328 @default.
- W2897950504 hasRelatedWork W2753224513 @default.
- W2897950504 hasRelatedWork W2818881888 @default.
- W2897950504 hasRelatedWork W2898074243 @default.
- W2897950504 hasRelatedWork W2980456499 @default.
- W2897950504 hasRelatedWork W3144569210 @default.
- W2897950504 hasRelatedWork W3168094351 @default.
- W2897950504 hasVolume "2" @default.
- W2897950504 isParatext "false" @default.
- W2897950504 isRetracted "false" @default.
- W2897950504 magId "2897950504" @default.
- W2897950504 workType "article" @default.