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• W2897952003 abstract "<b><i>Background:</i></b> Studies demonstrating an association between anesthesia and brain cell death (neuroapoptosis) in young animals were performed without accompanying surgery. This study tests the hypothesis that fetal surgery decreases anesthesia-induced neuroapoptosis. <b><i>Materials and Methods:</i></b> Seventy-day-pregnant ewes received 2% isoflurane for 1 h (low dose [LD]) or 4% for 3 h (high dose [HD]) with or without fetal surgery (S). Unexposed fetuses served as controls (C). Fetal brains were processed for neuroapoptosis using anti-caspase-3 antibodies. Data were analyzed using ANOVA. <b><i>Results:</i></b> Twenty-eight fetal sheep were evaluated. Dentate gyrus neuroapoptosis was lower in the HD+S group (13.1 ± 3.76 × 10⁵/mm³) than in the HD (19.1 ± 1.40 × 10⁵/mm³, <i>p</i> = 0.012) and C groups (18.3 ± 3.55 × 10⁵/mm³, <i>p</i> = 0.035). In the pyramidal layer of the hippocampus, neuroapoptosis was lower in the HD+S group (8.11 ± 4.88 × 10⁵/mm³) than in the HD (14.8 ± 2.82 × 10⁵/mm³, <i>p</i> = 0.006) and C groups (14.1 ± 4.54 × 10⁵/mm³, <i>p</i> = 0.019). The LD+S group showed a trend towards a significant decrease in neuroapoptosis in the pyramidal layer (LD+S 7.51 ± 1.48 vs. LD 13.5 ± 1.87 vs. C 14.1 ± 4.54 × 10⁵/mm³, <i>p</i> = 0.07) but not in the dentate gyrus. Fetal surgery did not affect neuroapoptosis in the frontal cortex or endplate. <b><i>Conclusions:</i></b> Fetal surgery decreases isoflurane-induced neuroapoptosis in the dentate gyrus and the pyramidal layer of mid-gestational fetal sheep. Long-term effects of these observations on memory and learning deserve further exploration." @default.
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• W2897952003 date "2018-10-12" @default.
• W2897952003 modified "2023-09-22" @default.
• W2897952003 title "Fetal Surgery Decreases Anesthesia-Induced Neuroapoptosis in the Mid-Gestational Fetal Ovine Brain" @default.
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• W2897952003 doi "https://doi.org/10.1159/000491925" @default.
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