Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897952982> ?p ?o ?g. }
- W2897952982 endingPage "4305" @default.
- W2897952982 startingPage "4288" @default.
- W2897952982 abstract "Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and its incidence is expected to increase. Despite tremendous efforts to understand its underlying biological mechanisms, MDD pathophysiology remains elusive and pharmacotherapy outcomes are still far from ideal. Low-grade chronic inflammation seems to play a key role in mediating the interface between psychological stress, depressive symptomatology, altered intestinal microbiology, and MDD onset. We review the available pre-clinical and clinical evidence of an involvement of pro-inflammatory pathways in the pathogenesis, treatment, and remission of MDD. We focus on caspase 1, inducible nitric oxide synthase, and interferon gamma, three inflammatory systems dysregulated in MDD. Treatment strategies aiming at targeting such pathways alone or in combination with classical therapies could prove valuable in MDD. Further studies are needed to assess the safety and efficacy of immune modulation in MDD and other psychiatric disorders with neuroinflammatory components." @default.
- W2897952982 created "2018-10-26" @default.
- W2897952982 creator A5001285588 @default.
- W2897952982 creator A5001946546 @default.
- W2897952982 creator A5010443893 @default.
- W2897952982 creator A5021913455 @default.
- W2897952982 creator A5084596637 @default.
- W2897952982 date "2018-10-10" @default.
- W2897952982 modified "2023-10-18" @default.
- W2897952982 title "Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma" @default.
- W2897952982 cites W138664006 @default.
- W2897952982 cites W1505097575 @default.
- W2897952982 cites W1515023627 @default.
- W2897952982 cites W1519815858 @default.
- W2897952982 cites W1546743948 @default.
- W2897952982 cites W1560867514 @default.
- W2897952982 cites W1561041814 @default.
- W2897952982 cites W1571910978 @default.
- W2897952982 cites W1588685142 @default.
- W2897952982 cites W162257389 @default.
- W2897952982 cites W1834981029 @default.
- W2897952982 cites W1883906051 @default.
- W2897952982 cites W1908076156 @default.
- W2897952982 cites W1923506064 @default.
- W2897952982 cites W1955944566 @default.
- W2897952982 cites W1963723844 @default.
- W2897952982 cites W1965069010 @default.
- W2897952982 cites W1966170485 @default.
- W2897952982 cites W1966761389 @default.
- W2897952982 cites W1968398347 @default.
- W2897952982 cites W1969106504 @default.
- W2897952982 cites W1969539443 @default.
- W2897952982 cites W1970196749 @default.
- W2897952982 cites W1971346646 @default.
- W2897952982 cites W1971915082 @default.
- W2897952982 cites W1974409272 @default.
- W2897952982 cites W1977804070 @default.
- W2897952982 cites W1979096652 @default.
- W2897952982 cites W1981500982 @default.
- W2897952982 cites W1982775265 @default.
- W2897952982 cites W1983899648 @default.
- W2897952982 cites W1984781297 @default.
- W2897952982 cites W1985001669 @default.
- W2897952982 cites W1985031521 @default.
- W2897952982 cites W1985438873 @default.
- W2897952982 cites W1986875797 @default.
- W2897952982 cites W1987535382 @default.
- W2897952982 cites W1987645065 @default.
- W2897952982 cites W1987906603 @default.
- W2897952982 cites W1988563263 @default.
- W2897952982 cites W1988681677 @default.
- W2897952982 cites W1988788559 @default.
- W2897952982 cites W1989029694 @default.
- W2897952982 cites W1990724076 @default.
- W2897952982 cites W1991412103 @default.
- W2897952982 cites W1992144053 @default.
- W2897952982 cites W1994756087 @default.
- W2897952982 cites W1995194119 @default.
- W2897952982 cites W1996386643 @default.
- W2897952982 cites W1996454121 @default.
- W2897952982 cites W1999867088 @default.
- W2897952982 cites W2000230976 @default.
- W2897952982 cites W2002250647 @default.
- W2897952982 cites W2003062523 @default.
- W2897952982 cites W2004243143 @default.
- W2897952982 cites W2004462939 @default.
- W2897952982 cites W2004934829 @default.
- W2897952982 cites W2005886168 @default.
- W2897952982 cites W2006009013 @default.
- W2897952982 cites W2007549067 @default.
- W2897952982 cites W2008206181 @default.
- W2897952982 cites W2008261126 @default.
- W2897952982 cites W2008365333 @default.
- W2897952982 cites W2008630639 @default.
- W2897952982 cites W2008893382 @default.
- W2897952982 cites W2010293066 @default.
- W2897952982 cites W2012490955 @default.
- W2897952982 cites W2012953866 @default.
- W2897952982 cites W2013036001 @default.
- W2897952982 cites W2013980575 @default.
- W2897952982 cites W2014381681 @default.
- W2897952982 cites W2016056242 @default.
- W2897952982 cites W2016209226 @default.
- W2897952982 cites W2017139139 @default.
- W2897952982 cites W2017421171 @default.
- W2897952982 cites W2018669711 @default.
- W2897952982 cites W2018933100 @default.
- W2897952982 cites W2019383068 @default.
- W2897952982 cites W2019465027 @default.
- W2897952982 cites W2019726878 @default.
- W2897952982 cites W2021779583 @default.
- W2897952982 cites W2021915895 @default.
- W2897952982 cites W2022241882 @default.
- W2897952982 cites W2022619682 @default.
- W2897952982 cites W2026161448 @default.
- W2897952982 cites W2028598063 @default.
- W2897952982 cites W2028860498 @default.
- W2897952982 cites W2028980996 @default.