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- W2897953562 abstract "// Laura Gramantieri 1, * , Michele Baglioni 1, * , Francesca Fornari 1, 2 , Maria Antonella Laginestra 3 , Manuela Ferracin 3 , Valentina Indio 4 , Matteo Ravaioli 5 , Matteo Cescon 2, 5 , Vanessa De Pace 5 , Simona Leoni 1 , Camelia Alexandra Coadă 1 , Massimo Negrini 6 , Luigi Bolondi 1, 2 and Catia Giovannini 1, 2 1 Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, Bologna, Italy 2 Department of Medical and Surgical Sciences, DIMEC, University of Bologna, Bologna, Italy 3 Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy 4 “Giorgio Prodi” Cancer Research Center, University of Bologna, Bologna, Italy 5 General Surgery and Transplant Unit, Sant’Orsola-Malpighi University Hospital, Bologna, Italy 6 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy * These authors have contributed equally to this work Correspondence to: Laura Gramantieri, email: laura.gramantieri@aosp.bo.it Catia Giovannini, email: catia.giovannini4@unibo.it Keywords: hepatocellular carcinoma; LUCAT1; CASC9; biomarkers Received: March 07, 2018 Accepted: September 01, 2018 Published: October 12, 2018 ABSTRACT Long non-coding RNAs (lncRNAs) are ncRNAs more than 200 nucleotides long that participate to a wide range of biological functions. However, their role in cancer is poorly known. By using an NGS-based approach we analyzed the intragenic and poliA-lncRNAs in hepatocellular carcinoma (HCC) and we assayed the relationships between their deregulated expression and clinical-pathological characteristics. The expression profile of lncRNAs was studied in a discovery series of 28 HCC and matched cirrhosis and was validated in an independent cohort of 32 HCC patients both in tissue and serum. The correlation between lncRNA expression and clinical-pathological variables, EMT markers and putative sponged microRNAs level were investigated. Functional experiments were performed in HCC-derived cell lines to clarify the role of selected lncRNAs in HCC. A panel of deregulated lncRNAs differentiated HCC from cirrhotic tissue. CASC9 and LUCAT1 were up-regulated in a subset of HCC-derived cell lines and in half of HCCs which displayed a lower recurrence after surgery. LUCAT1 and CASC9 silencing increased cell motility and invasion capability in HCC cells and influenced the EMT phenotype. LUCAT1 was demonstrated to directly sponge the onco-miR-181d-5p. Both LUCAT1 and CASC9 were secreted in exosomes, and higher circulating CASC9 levels were associated with tumor size and HCC recurrence after surgery, suggesting its potential usage as putative non-invasive prognostic biomarker of recurrence." @default.
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- W2897953562 date "2018-10-12" @default.
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- W2897953562 title "LncRNAs as novel players in hepatocellular carcinoma recurrence" @default.
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- W2897953562 doi "https://doi.org/10.18632/oncotarget.26202" @default.
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