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- W2897954952 abstract "Abstract Methane-oxidizing microbes catalyze the oxidation of the greenhouse gas methane using the copper-dependent enzyme particulate methane monooxygenase (pMMO). Isolated pMMO exhibits lower activity than whole cells, however, suggesting that additional components may be required. A pMMO homolog, ammonia monooxygenase (AMO), converts ammonia to hydroxylamine in ammonia-oxidizing bacteria (AOB) which produce another potent greenhouse gas, nitrous oxide. Here we show that PmoD, a protein encoded within many pmo operons that is homologous to the AmoD proteins encoded within AOB amo operons, forms a copper center that exhibits the features of a well-defined Cu A site using a previously unobserved ligand set derived from a cupredoxin homodimer. PmoD is critical for copper-dependent growth on methane, and genetic analyses strongly support a role directly related to pMMO and AMO. These findings identify a copper-binding protein that may represent a missing link in the function of enzymes critical to the global carbon and nitrogen cycles." @default.
- W2897954952 created "2018-10-26" @default.
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- W2897954952 date "2018-10-15" @default.
- W2897954952 modified "2023-10-14" @default.
- W2897954952 title "Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria" @default.
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- W2897954952 doi "https://doi.org/10.1038/s41467-018-06681-5" @default.
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