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• W2897958267 abstract "Abstract Protein stability is affected at different hierarchies – gene, RNA, amino acid sequence and structure. Gene is the first level which contributes via varying codon compositions. Codon selectivity of an organism differs with normal and extremophilic milieu . The present work attempts at detailing the codon usage pattern of six extremophilic classes and their harmony. Homologous gene datasets of thermophile-mesophile, psychrophile-mesophile, thermophile-psychrophile, acidophile-alkaliphile, halophile-nonhalophile and barophile-nonbarophile were analysed for filtering statistically significant attributes. Relative abundance analysis, 1–9 scale ranking, nucleotide compositions, attribute weighting and machine learning algorithms were employed to arrive at findings. AGG in thermophiles and barophiles, CAA in mesophiles and psychrophiles, TGG in acidophiles, GAG in alkaliphiles and GAC in halophiles had highest preference. Preference of GC-rich and G/C-ending codons were observed in halophiles and barophiles whereas, a decreasing trend was reflected in psychrophiles and alkaliphiles. GC-rich codons were found to decrease and G/C-ending codons increased in thermophiles whereas, acidophiles showed equal contents of GC-rich and G/C-ending codons. Codon usage patterns exhibited harmony among different extremophiles and has been detailed. However, the codon attribute preferences and their selectivity of extremophiles varied in comparison to non-extremophiles. The finding can be instrumental in codon optimization application for heterologous expression of extremophilic proteins." @default.
• W2897958267 created "2018-10-26" @default.
• W2897958267 creator A5011409257 @default.
• W2897958267 creator A5033520366 @default.
• W2897958267 date "2018-10-19" @default.
• W2897958267 modified "2023-10-14" @default.
• W2897958267 title "Deciphering the rationale behind specific codon usage pattern in extremophiles" @default.
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• W2897958267 doi "https://doi.org/10.1038/s41598-018-33476-x" @default.
• W2897958267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195531" @default.
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• W2897958267 hasPublicationYear "2018" @default.
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