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• W2897964327 abstract "Abstract Introduction We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [ 11 C]PIB–positron emission tomography ([ 11 C]PIB‐PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ‐PET quantification. Methods Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. Results CL values increased with each CERAD neuritic plaque score increment (median −3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. PET‐pathology associations were comparable across sites and unchanged when restricting the analyses to the 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate‐to‐frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate‐to‐high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). Discussion Our study demonstrated the robustness of a multisite Centiloid [ 11 C]PIB‐PET study and established a range of pathology‐based CL thresholds." @default.
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• W2897964327 date "2018-10-19" @default.
• W2897964327 modified "2023-10-09" @default.
• W2897964327 title "Multisite study of the relationships between <i>antemortem</i> [¹¹C]PIB‐PET Centiloid values and <i>postmortem</i> measures of Alzheimer's disease neuropathology" @default.
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• W2897964327 doi "https://doi.org/10.1016/j.jalz.2018.09.001" @default.
• W2897964327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6368897" @default.
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