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- W2897964598 abstract "IgG4-related disease (IgG4-RD) is a newly defined multi-organ disease proposed by Japanese physicians. IgG4-RD is characterized by elevated serum levels of IgG4 and massive infiltration of IgG4-expressing plasma cells in the affected organs. Recent studies have shown that abnormal adaptive immune responses mediated by T helper type 2 cells, regulatory T cells, follicular helper T cells, cytotoxic CD4+ T cells, and plasmablasts are involved in IgG4-RD immunopathogenesis. In addition to adaptive immune responses, innate immune responses play pathogenic roles in IgG4-RD. Plasmacytoid dendritic cells (pDCs), M2 macrophages, and basophils are activated to produce various kinds of cytokines in IgG4-RD. Recent studies highlight the importance of type I IFN and IL-33 produced by pDCs in IgG4-RD immunopathogenesis." @default.
- W2897964598 created "2018-10-26" @default.
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- W2897964598 date "2018-12-11" @default.
- W2897964598 modified "2023-10-16" @default.
- W2897964598 title "Cytokines produced by innate immune cells in IgG4-related disease" @default.
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- W2897964598 doi "https://doi.org/10.1080/14397595.2018.1536364" @default.
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