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- W2897966642 abstract "In non-small cell lung cancer (NSCLC), the pathologist has contributed to the development of personalized medicine from the determination of the right histological type to EGFR and ALK/ROS1 molecular screening for targeted therapies. With the development of immunotherapies, pathologists intervene forefront with programmed death-ligand 1 (PD-L1) immunohistochemical testing, companion test for pembrolizumab monotherapy, first line and complementary test to the other programmed cell death-1 (PD-1) PD-L1 inhibitors. Recently, tumor mutational burden has emerged as a promising tool to evaluate sensitivity to immunotherapy (IO). The pathologist has a crucial role in the setting of tumor mutational burden (TMB) testing for the selection and the preparation of the sample for high throughput molecular analysis, and in the first steps of the next-generation sequencing (NGS) workflow." @default.
- W2897966642 created "2018-10-26" @default.
- W2897966642 creator A5054491719 @default.
- W2897966642 creator A5061340891 @default.
- W2897966642 date "2018-12-01" @default.
- W2897966642 modified "2023-10-14" @default.
- W2897966642 title "Tumor mutational burden in non-small cell lung cancer—the pathologist’s point of view" @default.
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- W2897966642 doi "https://doi.org/10.21037/tlcr.2018.09.26" @default.
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