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• W2897974487 abstract "Aim: To evaluate genetic variants affecting mycophenolic acid (MPA) metabolism in Chinese renal transplant recipients. Methods: Total 11 SNPs of UGT1A9, UGT1A8, UGT2B7, ABCC2, ABCG2 and SLCO1B3 were genotyped in 408 Chinese renal transplant recipients. Associations between SNPs and MPA concentration/dose ratio (C 0 /D) were analyzed using different genetic models. Multivariate linear regression was used to analyze associations between log (C 0 /D) and clinical factors. Results: After adjustment by clinical factors, UGT2B7 rs7662029 was associated with log (C 0 /D) using a dominant (p = 0.041) and an additive (p = 0.038) model, ABCC2 rs717620 was associated with log (C 0 /D) using a recessive model (p = 0.019). Using additive model, SNP–SNP interactions were identified (p = 0.002) between ABCC2 rs717620 and UGT1A9 rs2741049, with interactions (p = 0.002) between ABCC2 rs717620 and UGT1A8 rs1042597. Age, albumin and serum creatinine were associated with log (C 0 /D). Conclusion: rs7662029 and rs717620 may affect MPA pharmacokinetics. SNP–SNP interactions and clinical factors may have significant effects on MPA metabolism." @default.
• W2897974487 created "2018-10-26" @default.
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• W2897974487 date "2018-11-01" @default.
• W2897974487 modified "2023-10-16" @default.
• W2897974487 title "Impact of <i>UGT2B7</i> and <i>ABCC2</i> genetic polymorphisms on mycophenolic acid metabolism in Chinese renal transplant recipients" @default.
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• W2897974487 doi "https://doi.org/10.2217/pgs-2018-0114" @default.
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